BACKGROUND Several different methods have been used to assess pulmonary permeability in response to acute lung injury (ALI). However, these methods often involve complicated procedures and algorithms that are difficult to precisely control. The purpose of the current study is to establish a feasible method to evaluate alterations in lung permeability by instilling fluorescently labeled dextran ...

[1] Models of hydrothermal groundwater circulation can quantify limits to the role of hydrothermal activity in Martian crustal processes. We present here the results of numerical simulations of convection in a porous medium due to the presence of a hot intruded magma chamber. The parameter space includes magma chamber depth, volume, aspect ratio, and host rock permeability and porosity. A prima...

permeability can be directly measured using cores taken from the reservoir in the laboratory. due to high cost associated with coring, cores are available in a limited number of wells in a field. many empirical models, statistical methods, and intelligent techniques were suggested to predict permeability in un-cored wells from easy-to-obtain and frequent data such as wireline logs. the main obj...

Kaposi sarcoma (KS) is the most common tumor associated with HIV-1 infection and develops in nearly 30% of cases. The principal features of this tumor are abnormal vascularization and the proliferation of endothelial cells and spindle (tumor) cells. KS-derived spindle cells induce vascular lesions and display enhanced vascular permeability when inoculated subcutaneously in the nude mouse. This ...

A calcein fluorescence quenching method was applied to measure osmotic water permeability in highly differentiated primary cultures of brain astrocytes from wild-type and aquaporin-4 (AQP-4)-deficient mice. Cells grown on coverglasses were loaded with calcein for measurement of volume changes after osmotic challenge. Hypotonic shock producing twofold cell swelling resulted in a reversible appro...

Cross-property relations linking the fluid permeability k associated with viscous flow through a porous medium to effective diffusion properties of the medium have recently been derived. Torquato [Phys. Rev. Lett. 64,2644 (1990)] found that k<D4,7, where r is the “mean survival time” associated with steady-state diffusion of “reactants” in the fluid region of diffusion coefficient D and porosit...

In pressure sensitive reservoirs, interaction effects among the porous media flow field, the fracture field and the stress field can cause some specific flow characteristics entirely different from those in conventional reservoirs. Dynamic fracture behavior is one of them, which generates a change in the value of fracture aperture and even a variation in the anisotropy of permeability. In this ...

A metric of nanoparticle toxicity is the passive permeability rate through cellular membranes. To assess the influence of nanoparticle morphology on this process, the permeability of buckyball-sized molecules through a representative lipid bilayer was investigated by molecular-dynamics simulation. When C(60) was compared with a prototypical opened C(60) molecule and a representative combustion-...

BACKGROUND Severe burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear. Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function. We hypothesized that the MLCK-dependent MLC phosphorylation mediates the regulation of intestinal barrier functi...