Doxorubicin (Dox) is a common chemotherapeutic anticancer drug. One of its side effect, according to some studies is oxidative stress-induced toxic changes on the liver. In this study protective efficacy of Proanthocyanidin (GSPE) along with vitamin E on Dox induced hepatotoxicity was evaluated in 50 male (divided in to five groups) Wister rats. After 2 weeks of the experiment and drug administ...

BACKGROUND Many oxidative stress related diseases are as a result of accumulation of free radicals in the body. A lot of researches are going on worldwide directed towards finding natural antioxidants of plants origins. The aims of this study were to evaluate in vitro antioxidant activities and to screen for phytochemical constituents of Helichrysum longifolium DC. [Family Asteraceae] aqueous c...

BACKGROUND AND PURPOSE Tissue hardness (induration), pain and tenderness are common late adverse effects of curative radiotherapy for early breast cancer. The purpose of this study was to test the efficacy of IH636 grape seed proanthocyanidin extract (GSPE) in patients with tissue induration after high-dose radiotherapy for early breast cancer in a double-blind placebo-controlled randomised pha...

Proanthocyanidins, which are composed of oligomeric flavan-3-ol units, are contained in various foodstuffs (e.g., fruits, vegetables, and drinks) and are strongly biologically active compounds. We investigated which element of the proanthocyanidin structure is primarily responsible for this functionality. In this study, we elucidate the importance of the upper-unit of 4-8 condensed dimeric flav...

BACKGROUND Aiming the continuity of the studies of Austroplenckia populnea, Brazilian species of the Celastraceae family, in the present study, it was investigated the effect of crude extracts obtained with ethanol, ethyl acetate and chloroform and two purified constituents, proanthocyanidin A and 4'-O-methylepigallocatechin, both isolated from its samaras, on cancer cell proliferation assays. ...

The proanthocyanidins or condensed tannins, phenolic polymers which are synthesized by many plants, characteristically bind and precipitate proteins. The specificity of the interaction was investigated using a competitive binding assay to compare directly the affinities of various proteins and synthetic polymers for the tannin obtained from Sorghum bicolor (Lin.) Moench. At pH 4.9, the relative...

Flavonoids, including proanthocyanidins (PAs, also called condensed tannins), play a multitude of roles in plants (Winkel-Shirley, 2001). The presence of certain types of flavonoids in crops is associated with desirable and important agronomic traits, and metabolic engineering of flavonoid biosynthesis has therefore attracted considerable interest (Dixon, 2005). PAs are oligomers or polymers of...