In this paper, we describe the design issues and technical implementation of an interactive Family Message Board. The Family Message Board enables members of a distributed family to communicate with one another both synchronously and asynchronously via simple, pen-based, digital notes. Each household running this Java-based software can view, create, and manipulate notes in a zoomable space. Th...

BACKGROUND There is growing interest in assisted living technologies to support independence at home. Such technologies should ideally be designed 'in the wild' i.e. taking account of how real people live in real homes and communities. The ATHENE (Assistive Technologies for Healthy Living in Elders: Needs Assessment by Ethnography) project seeks to illuminate the living needs of older people an...

By utilizing different communication channels, such as verbal language, gestures or facial expressions, virtually embodied interactive humans hold a unique potential to bridge the gap between human-computer interaction and actual interhuman communication. The use of virtual humans is consequently becoming increasingly popular in a wide range of areas where such a natural communication might be ...

The nanopore sensor can detect cancer-derived nucleic acid biomarkers such as microRNAs (miRNAs), providing a noninvasive tool potentially useful in medical diagnostics. However, the nanopore-based detection of these biomarkers remains confounded by the presence of numerous other nucleic acid species found in biofluid extracts. Their nonspecific interactions with the nanopore inevitably contami...

In this paper, we describe the design issues and te chnical implementation of an interactive Family Message Boa rd. The Family Message Board enables members of a distributed family to communicate with one another both synchronously and asynchronously via simple, pen-ba sed, digital notes. Each household running this Java-bas ed software can view, create, and manipulate notes in a zoomable space...

Nanotechnology-based materials are beginning to emerge as promising platforms for biomedical analysis, but measurement and control at the cell-chip interface remain challenging. This idea served as the basis for discussion in a focus group at the recent National Academies Keck Futures Initiative. In this Perspective, we first outline recent advances and limitations in measuring nanoscale mechan...

Targeted enrichment of conserved genomic regions is a popular method for collecting large amounts of sequence data from non-model taxa for phylogenetic, phylogeographic, and population genetic studies. Yet, few open-source workflows are available to identify conserved genomic elements shared among divergent taxa and to design enrichment baits targeting these regions. These shortcomings limit th...

a “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome p450 enzymes in one session. some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. our presented work was to aim on the influence of bupropion on rat cytochrome p450-mediated metabolism of tolbutamide. the biotransformation rates of tolbutam...

Abstract Accurate designing of polymerase chain reaction (PCR) primers targeting conserved segments in viral genomes is desirable for preventing false-negative results and decreasing the need standardization across different PCR protocols. In this work, we designed described a set probes regions identified from multiple sequence alignment 2341 Severe Acute Respiratory Syndrome Coronavirus 2 (SA...

susceptibility-weighted imaging (swi) has continued to develop into a powerful clinical tool to visualize venous structures and iron in the brain and to study diverse pathologic conditions. it is a new art which evaluates and exploits the properties of blood, iron and other tissues. it is a magnitude or filtered phase images or combination of both, obtained with high-resolution 3d fully velocit...