Current biopharmaceutical manufacturing systems are not compatible with portable or distributed production of biologics, as they typically require the development of single biologic-producing cell lines followed by their cultivation at very large scales. Therefore, it remains challenging to treat patients in short time frames, especially in remote locations with limited infrastructure. To overc...

The Wiki-WS platform was implemented within the C2NIWA project for production purposes. Wiki-WS stands for developing, managing and maintaining web services. The production deployment needed implementation of several functional improvements and establishing a strong security&safety policy. The WikiWiki-WS platform has to be used as an educational environment for developing web services and a pr...

A n increasing number of clinical trials, and the recent approval of the first gene therapy in Europe, alipogene tiparvovec (Glybera®, uniQure), holds promise for recombinant adeno-associated virus (rAAV) to become a mainstay in clinical practice. Since the molecular cloning of AAV in the 1980s, a plethora of production protocols/manufacturing systems for generating rAAV vectors have been devel...

This paper presents the prototype of an advanced platform for production analysis and optimization, referred to as ProOpter. The platform was developed to support the recently derived concept of holistic production control (HPC), which relies on model-based control. The prototype is comprised of a set of offline and on-line modules. The off-line modules support the definition of key performance...

The mobile agent technology provides facilities that enable to reduce the complexity of telecommunication services development. However the major part of this development is still devoted to the code production. In order to optimize the development of services, this production should be reduced while the main part must become an upstream activity, i.e., the elaboration of specifications. This p...

Plant-based systems are considered a valuable platform for the production of recombinant proteins as a result of their well-documented potential for the flexible, low-cost production of high-quality, bioactive products. In this study, we compared the expression of a target human recombinant protein in traditional fermenter-based cell cultures (bacterial and insect) with plant-based expression s...