Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog...

Histiocytic sarcoma is a rare, aggressive neoplasm that responds poorly to therapy. Histiocytic sarcoma is thought to arise from macrophage precursor cells via genetic changes that are largely undefined. To improve our understanding of the etiology of histiocytic sarcoma we conducted a forward genetic screen in mice using the Sleeping Beauty transposon as a mutagen to identify genetic drivers o...

Kikuchi-Fujimoto's disease (histiocytic necrotizing lymphadenitis) is a benign, self-limited disease of unknown cause that often presents with persistently enlarged cervical lymph nodes that are unresponsive to antibiotic therapy. The disease should be considered in the differential diagnosis of cervical lymphadenopaty: viral infection, tuberculosis, hyperplastic lymphadenopathy, and metastatic...

The authors present a case of Kikuchi's disease associated with systemic lupus erythematosus (SLE) and autoimmune-like hepatitis. Kikuchi's disease, or histiocytic necrotizing lymphadenitis is occasionally associated with SLE and mildly elevated aminotransferases. A 17-year old woman presented with fever, arthritis and bilateral cervical adenopathy. Histopathological and immunohistochemical exa...

the pre.sent rep.or,t describes the morphological and if nod h pron erative aspects of lymph es iii odgkin s disease grown in tissue culture. the development of hodgkin's lymph-nodes grown in vitro seems to depend upon the  a~e of t~e person and the stage of the hodgkin's disease at the time the i h is obtained. ymp - the morphological and the proliferative aspects ('helralcterizi~d of hodgkin'...

Rosai-Dorfman disease is a rare histiocytic disorder, clinically characterized by massive, bilateral painless cervical lymphadenopathy with potential for extranodal manifestations. We report a 45-year-old male patient who presented with a slowly growing erythematous nodule of the left chin. The mass appeared non-vascular on computed tomography study, but ultrasonogram was suggestive of a vascul...

Kikuchi disease, also called Kikuchi-Fujimoto disease or Kikuchi's histiocytic necrotizing lymphadenitis, is a rare, benign condition of unknown cause, usually characterized by cervical lymphadenopathy and fever. The diagnosis is based on histopathology. Our patient was a woman with bilateral cervical lymphadenopathy, fever, chest and abdominal pain, fatigue, maculopapular rash on her face, tru...

The distribution of muramidase (lysozyme) in normal and pathological human tissues has been studied, using an immunohistological technique. The enzyme was demonstrated in a variety of healthy tissues, including serous salivary acinar cells, lactating mammary tissue, Paneth cells, renal tubular cells, myeloid cells (including eosinophils), and histiocytic cells. In pathological tissues the most ...

Cytophagic histiocytic panniculitis (CHP) was first described in 1980. It classically presents with intermittent recurrent episodes of pyrexia subcutaneous nodules, pancytopenia and liver dysfunction, but most patients have in addition a multitude of other manifestations which confuse the clinical picture. Despite the variable clinical course, the disease is often fatal. Diagnosis is based on h...

Juvenile xanthogranuloma (JXG) is a benign histiocytic disease of uncertain pathogenesis that usually appears as a cutaneous lesion(s) in the head and neck region of young children. Diagnosis is based on histological examination that shows a nodular, dense infiltrate of polygonal or spindled mononuclear cells with moderate amounts of cytoplasm and scattered Touton giant cells. Juvenile xanthogr...