BACKGROUND Although many electrocardiographic abnormalities have been reported previously, prolonged QTC interval represented as the most important ECG finding in patients with liver cirrhosis. Echocardiography can detect structural cardiac abnormalities in cirrhotic patients. OBJECTIVES The present study aimed to determine the correlation between QTC prolongation and echocardiographic findin...

Background: Azithromycin maintenance therapy is widely used in cystic fibrosis (CF), but little known about its long-term safety. We investigated whether chronic azithromycin use safe regarding renal function, hepatic cell toxicity and QTc-interval prolongation.Methods: Adult CF patients (72 using for a cumulative period of 364.8 years 19 controls, 108.8 years) from two CF-centers the Netherlan...

It has been proposed that some deaths attributed to methadone are related to prolongation of the QTc interval; however, there are no clear recommendations on electrocardiogram (ECG) monitoring in patients undergoing intravenous methadone infusion. This is a report on a patient receiving methadone intravenous patient-controlled analgesia titration for the treatment of chronic pain. Initially, he...

Background: Identifying the sources of variation in QTc measurements is important for preventing arrhythmias during and after hemodialysis. The present study was designed to determine the correlation between the type of hemodialysis buffer and the changes in QTc interval in patients on chronic hemodialysis. Methods: Fifty-nine patients on chronic hemodialysis who referred in winter 2007 to hemo...

BACKGROUND At dosages above 0.1 mg/kg, droperidol induces a dose-dependent QTc interval prolongation. Although subject to controversy, low-dose droperidol has recently been suspected to induce cardiac arrhythmias. Hence, 5-hydroxytryptamine type 3 antagonists have become the first-line drug for management of postoperative nausea and vomiting. These drugs are also known to prolong the QTc interv...

Background Prolongation of the corrected QT (QTc) interval is well known for many drugs, some of which are an integral part of the therapeutic regimen after lung transplantation (LTX). Therefore, we investigated the QTc interval after LTX in the present study. Patients and Methods The medical records of patients after LTX were studied for demographic data, indication of LTX, medication, and b...

It is well known that imbalances in the dietary electrolytes are associated with a significantly higher incidence of cardiovascular disease (CVD). On the other hand, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of cardiac autonomic nervous system dysfunction, the incidence of CVD and sudden cardiac death. This study was designed to clarify the associat...

A 9-year-old boy diagnosed as Propionic acidemia at 2 months of age, complained of palpitations and nearsyncope episodes related with exercise. His metabolic condition was well controlled on sodium benzoate, carnitine, protein-free diet and biotin treatment. A prolonged QTc interval was noted on ECG-Holter (Fig. 1). Echocardiography showed no anomalies. He fulfilled criteria for diagnosis of Lo...

We performed this study to determine whether electrocardiographic corrected QT (QTc) interval predicts alterations in sympathovagal balance during orthostatic intolerance (OI). We reviewed 1,368 patients presenting with symptoms suggestive of OI who underwent electrocardiography and composite autonomic function tests (AFTs). Patients with a positive response to the head-up tilt test were classi...