In line with our studies on propafenone-type inhibitors of P-glycoprotein (P-gp), we applied several methods to approach virtual screening tools for identification of new P-gp inhibitors on one hand and the molecular basis of ligand-protein interaction on the other hand. For virtual screening, a combination of autocorrelation vectors and selforganising artificial neural networks proved extremel...

Full and unambiguous asssignment of all Hand C-NMR resonances of the free bases as well as the hydrochloride salts of the antiarrhythmic agent propafenone and a thiophene analogue in different solutions (DMSO-d6, CDCl3) is reported.

Abstract The article presents data on the most commonly used antiarrhythmic drugs of subclass IC: propafenone, flecainide, and a drug manufactured in Latvia — ethacizine. features priority areas each use were identified. author conducted critical analysis results Cardiac Arrhythmia Suppression Trials (CAST)-I CAST-II suggested ways to further study IC context current treatment strategies. CAST-...

Background: In the daily clinical practice, patients with atrial fibrillation (AF) lasting more than 48h (or not datable at all) are not uncommon. In long-lasting AF changes in electrophysiological features (electrical remodeling) can occur, resulting in a loss of sensibility to most antiarrhythmic drugs. There is strong evidence that the main mechanism involved in electrical remodeling is a gl...

Restoring sinus rhythm (SR) in patients with atrial fibrillation (AF) relies on three main objectives: 1) to find and treat a predisposing factor; 2) to prevent thromboembolic complications and 3) to cardiovert as soon as possible to avoid atrial remodeling and obtain SR more easily [1-2]. For this last purpose, pharmacological or electrical cardioversion may be used. However, electrical cardio...

BACKGROUND A main side effect of antiarrhythmic drug therapy is the tendency of these drugs to promote arrhythmia within the therapeutic concentration range, i.e., the proarrhythmic activity of these drugs. However, a model for in vitro assessment, quantification, and comparison of proarrhythmic drug activities was still lacking, and only sparse data were available. METHODS AND RESULTS To ana...