PURPOSE To evaluate the rate of prophylactic contralateral mastectomy in an international cohort of women with hereditary breast cancer and to evaluate the predictors of uptake of preventive surgery. PATIENTS AND METHODS Women with a BRCA1 or BRCA2 mutation who had been diagnosed with unilateral breast cancer were followed prospectively for a minimum of 1.5 years. Information was collected on...

Prophylactic drug therapy is a major component of overall migraine management. However, because we do not know how currently used prophylactic drugs exert their beneficial effects in migraine, their use is based primarily on clinical trials. In general, prophylactic drugs are indicated when patients have three or more attacks a month and symptomatic medication use alone is not satisfactory. The...

background. this study evaluated the effect of two prophylaxis techniques on the marginal gap of ci v resin-modified glass-ionomer restorations. methods. standard cl v cavities were prepared on the buccal surfaces of 48 sound bovine mandibular incisors in this in vitro study. after restoration of the cavities with gc fuji ii lc resin-modified glass-ionomer, the samples were randomly assigned to...

Women who carry a germline mutation in the BRCA1 or BRCA2 (BRCA1/2) gene have a 50%–80% lifetime risk of developing breast cancer and a 10%–40% lifetime risk of developing ovarian cancer (1–4). These high-risk women are being offered various preventive measures, including surveillance, chemoprevention, and prophylactic surgery to reduce their risk of cancer. During a prophylactic bilateral mast...

BACKGROUND The past decade has seen an increasing prevalence of prophylactic mastectomy with decreasing ages of patients treated for breast cancer. Data are limited on the fiscal impacts of contralateral prophylactic mastectomy trends, and no study has compared bilateral prophylactic mastectomy with reconstruction to surveillance in high-risk patients. METHODS Lifetime third-party payer costs...

PURPOSE To systematically investigate the effectiveness of prophylactic surgeries (PS) implemented in women carrying BRCA1/2 mutations. EXPERIMENTAL DESIGN The PubMed database was searched till August 2014 and 15 studies met the inclusion criteria. Fixed- or random-effects models were conducted according to study heterogeneity. We calculated the pooled relative risks (RR) for cancer risk or m...