expression of receptor tyrosine kinase ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. our preliminary re-sults indicate the presence of a truncated transcript of ror1 in tumor cells. the trun-cated ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase domain (ror1-ecd). as enzyme activity is highly d...

objective: angiogenesis a process that results in neo-vascularization is an essential stage in growth of solid tumors and the formation of metastases. vascular endothelial growth factor (vegf) and its receptors, vegfr1 (flt-1) and vegfr2 (kdr/flk-1), are the major regulators for tumor angiogenesis. recent studies showed that second domain of vegfr-1is a key factor for vegf/vegfr-1 interaction. ...

background mycobacterium tuberculosis is a vicious microbe co-existing with the infected host. this pathogen exploited opportunities to spread during periods of urbanization and social upheaval, and got retreated with improved hygiene. objectives this investigation was designed to clone and characterize m. tuberculosis mutt gene, a homologue of a dna repair protein in escherichia coli. the aim ...

objective(s) staphylococcus aureus is a leading cause of many nosocomial and community acquired infections. according to many reports, antibiotic therapy can not guarantee the eradication of s. aureus infections. thus designing an adhesin based vaccine could restrain the s. aureus infections. this study designed for construction of a new fusion protein vaccine against s. aureus infections based...

Background and Aims: The novel approaches in influenza vaccination have targeted more conserved viral proteins such as nucleoprotein (NP) to provide cross protection against all serotypes of influenza A viruses. Influenza specific cytotoxic T lymphocytes (CTL) are able to lyse influenza-infected cells by recognition of NP, the major target molecule in virus for CTL responses. On the other hand,...

cloning and sequencing of a lipase gene from an indigenous bacillus pumilus, strain f3, revealed an open-reading frame of 648 nucleotides predicted to encode a protein of 215 residues. sequence analysis showed that f3 lipase contained a signal peptide composed of 34 amino acids with an h domain of 18 residues. a tat-like motif was found in the signal peptide similar to some other bacillus pumil...