objective(s):  the role of the apoptosis repressor with caspase recruitment domain (arc) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of endothelin-1 induced cardiac hypertrophy remains unknown. the present study discusses the inhibitory role of arc against endothelin–induced hypertrophy. results:in present study endothelin treated card...

fetuin-a is a phosphorylated glycoprotein produced by liver.it by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. fetuin-a acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blast...

We have shown previously, acute intraperitoneal administration of 2-deoxy-d-glucose (2DG) into Sprague-Dawley rats led to activation the adrenal medulla chromaffin cells, indicated with increased protein kinase activity and tyrosine hydroxylase (TH) phosphorylation, as well plasma adrenaline glucose levels. Here we used spontaneous hypertensive (SHR) Wistar Kyoto (WKY) investigate whether hyper...