A recent study of 30 soluble globular protein structures revealed a quasi-invariant called the hydrophobic ratio. This invariant, which is the ratio of the distance at which the second order hydrophobic moment vanished to the distance at which the zero order moment vanished, was found to be 0.75 +/- 0.05 for 30 protein structures. This report first describes the results of the hydrophobic profi...

Protein domains are conserved and functionally independent structures that play an important role in interactions among related proteins. Domain-domain interactions have been recently used to predict protein-protein interactions (PPI). In general, the interaction probability of a pair of domains is scored using a trained scoring function. Satisfying a threshold, the protein pairs carrying those...

Serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) appears to be an important diagnostic tool for a whole range of diseases. Sensitivities and specificities obtained with this new technology often seem superior to those obtained with current biomarkers. However, reproducibility and standardization are still problematic. The pr...

Elucidation of Protein-Protein Interactions (PPIs) in living cells/animals is very important for the study basic biology and development novel therapeutics. Recent advances techniques profiling PPIs, such as fluorescence microscopy various proximity labeling-based methods coupled with mass spectrometry (MS), have provided a great opportunity to PPIs their native states spatiotemporal resolution...

Non-Hodgkin's lymphoma comprises many related but distinct diseases and diagnosis and classification is complex. Protein profiling of lymphoma biopsies may be of potential value for use in this lymphoma classification and the discovery of novel markers. In this study, we have optimized a method for SELDI-TOF MS based protein profiling of frozen tissue sections, without dissection of tumour cell...

it is not clear what factors determine divergent outcomes of infections caused by h. pylori . in the present study, the protein profiles of different strains of h. pylori, isolated from three groups of patients with ulcerative disease, non-ulcerative gastritis and cancer disease, were analyzed using 1dsds-page. the patterns of different h. pylori strains were highly divergent. about 30.76% (7 b...

Next-generation precision antibody profiling; from science fiction to reality The purpose of the TopSpec project is develop tools establish sequence repertoire human antibodies and their respective antigens, better understand how organism defends itself against diseases. Results obtained confirm that this a breakthrough technology will revolutionise academic, clinical industrial proteomics dram...