conclusions the comprehensive analysis of a protein with important roles has never been easy, and in case of e2 envelope glycoprotein of hgv, there is no much data on its molecular and immunological features, clinical significance and its pathogenic potential in hepatitis or any other gbv-c related diseases. so, results of the present study may explain some structural, physiological and immunol...

to investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([pd(phen)(r-gly)]no3, r = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. these drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. human serum albumin is also important for drug d...

Protein secondary structure prediction has been satisfactorily performed by machine learning techniques such as support vector machines (SVM’s). We discuss a special technique to include hyrophobicity information to further improve the classification results. Hydrophobicity or hydrophobic moment measure of each amino acid is included within a given window length in the protein secondary structu...

Background & Objective: A main contest in chemotherapy is to obtain regulator above the biodistribution of cytotoxic drugs. The utmost promising strategy comprises of drugs coupled with a tumor-targeting bearer that results in wide cytotoxic activity and particular delivery. The B-subunit of Shiga toxin (STxB) is nontoxic and possesses low immunogenicity that exactly binds to t...

background: sigma factors are proteins that regulate transcription in bacteria. sigma factors can be activated in response to different environmental conditions. the rpos (rna polymerase, sigma s) gene encodes sigma-38 (σ38, or rpos), a 37.8 kda protein in pseudomonas aeruginosa (p. aeruginosa) strains. rpos is a central regulator of the general stress response and operates in both retroactive ...

prpc conversion to prpsc isoform is the main known cause for prion diseases including crutzfeldt-jakob, gerstmann-sträussler-sheinker syndrome and fatal familial insomnia in human. the precise mechanism underling this conversion is yet to be well understood. in the present work,  using the coordinate file of prpc (available on the protein data bank) as a starting structure, separate molecular d...

background and aims: since the produced recombinant proteins by molecular genetics techniques commonly have some limitations in the application, chimeric protein are introduced. chimeric proteins have found widespread application for the study of protein folding, structure stability, function and immunogenisity. methods: according to the known immunomodulatory effect and structure of hsp70 mole...

results phylogenetic analysis of the gene revealed that pakistani 1a hcv strains are in the start of third cluster and there is a difference between inter pakistani isolates at primary, secondary and tertiary levels. material and methods patient sera infected with hepatitis c virus, genotype 1a, were obtained from molecular diagnostics lab, cemb, university of the punjab lahore by using bd vacu...