W ITH increasing use of tests of the prothrombin concentration as an aid in the diagnosis of diseases of the liver and as a guide in vitamin K and dicumarol therapy,’6 it is imperative that the determinations be accurate. There are many ways of measuring the prothrombin concentration and each admits of numerous sources of error. Even when the most careful technic is practiced, appreciable error...

The initial experience of using Thrombotest instead of Quick's one-stage prothrombin time to control anticoagulant therapy is described.Patients well controlled by the Quick test are often found to be over-anticoagulated by Thrombotest standards, so the introduction of Thrombotest has led to widespread reductions in dosage. No improvement in stability of control has been noted. The main advanta...

A comparative study of the Fibrometer, Seratek, and manual technics measuring prothrombin time is described.Three technicians, 3 thromboplastin preparations, and 10 blood specimens with 10 replications were utilized in a 3 X 3 X 10 factorial design. It was found that the reproducibility of each method was subject to an interaction between technician, method, and reagent. In the hands of experie...

W ITH increasing use of tests of the prothrombin concentration as an aid in the diagnosis of diseases of the liver and as a guide in vitamin K and dicumarol therapy,’6 it is imperative that the determinations be accurate. There are many ways of measuring the prothrombin concentration and each admits of numerous sources of error. Even when the most careful technic is practiced, appreciable error...

BACKGROUND Fibrinogen and prothrombin have been suggested to become rate limiting in trauma associated coagulopathy. Administration of fibrinogen is now recommended, however, the importance of prothrombin to patient outcome is unknown. METHODS We have utilized two trauma patient databases (database 1 n = 358 and database 2 n = 331) to investigate the relationship of plasma prothrombin concent...

PURPOSE To characterize the imaging features of intracerebral hemorrhages in coagulopathies that alter prothrombin time or partial thromboplastin time. METHODS A fluid-blood level was defined as a horizontal interface between hypodense bloody serum layered above hyperdense settled blood. The prevalence of fluid-blood levels in acute intracerebral hemorrhages was determined on third-generation...

Background: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time (BT). ​​ Methods: Thirty-six APAP poisoned patients whose acetaminophen serum concentration were...

W ITH increasing use of tests of the prothrombin concentration as an aid in the diagnosis of diseases of the liver and as a guide in vitamin K and dicumarol therapy,’6 it is imperative that the determinations be accurate. There are many ways of measuring the prothrombin concentration and each admits of numerous sources of error. Even when the most careful technic is practiced, appreciable error...

medical profession with a very useful tool. This test is widely used today for control of anticoagulant therapy, as a preoperative test of hemostatic function, and as a liver function test, both in geriatric and pediatric practice. However, the methodology of the usual procedure either excludes or limits its employment for certain types of patients: the patient with poor or thronibosed VC1flS, ...