نتایج جستجو برای: proton mr spectroscopy
تعداد نتایج: 292308 فیلتر نتایج به سال:
SUMMARY: MR spectroscopy allows insight into the chemical composition of human tissue noninvasively. Thereby it can help to better characterize pathologic processes affecting the spinal cord andmay provide important clinicalmarkers for differential diagnosis. However, due to technical challenges, it has been rarely applied to the spinal cord. The aim of this review was to summarize the technica...
A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The art...
MR spectroscopy is a noninvasive technique that allows the detection of several naturally occurring compounds (metabolites) from well-defined regions of interest within the human brain. Alzheimer disease, a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. During the past 20 years, multiple studies have been performed on MR spectroscopy in patients wit...
BACKGROUND AND PURPOSE Administration of contrast material before proton MR spectroscopy may allow more accurate placement of the volume of interest, particularly in tumors; yet, some data have suggested that contrast material may alter the results of MR spectroscopy. To determine the validity of this contention, we performed pre- and postcontrast MR spectroscopy in patients with brain tumors a...
The advent of nuclear neuroimaging techniques has vastly changed neurobiology and neuroscience from a bench-research oriented practice to a clinical sub discipline with diagnostic and therapeutic implications. In particular, magnetic resonance spectroscopy (MR spectroscopy) began as a tool in understanding cellular metabolism in tissues of the prostate gland, kidney, and brain, and has since ev...
Purpose: To evaluate both a histogram based analysis of MR-derived cerebral blood volume maps and metabolite ratios from proton MR spectroscopy in order to exploit the ability of each method to characterize gliomas and to evaluate their combined diagnostic potential. Background: The value of normalized cerebral blood volume ratio (nCBV) analysis to differentiate high-grade (WHO grade III-IV) fr...
PURPOSE To evaluate the ability of proton MR spectroscopy to detect metabolic abnormalities in the seizure focus of humans with epilepsy. METHODS Single-voxel MR spectroscopy and MR imaging was performed in a group of 13 patients with a variety of seizure disorders and in the temporal lobes of 14 healthy volunteers. Signals from choline, creatine, N-acetyl-L-aspartate, and lactate were quanti...
PURPOSE To determine early signs of disease in patients with childhood-onset cerebral adrenoleukodystrophy (COCALD) with the use of proton MR spectroscopy. METHODS Eleven children with posterior COCALD involvement and three children with anterior COCALD involvement were studied with single-voxel proton MR spectroscopy and neuropsychological testing. Findings were compared with those in five h...
BACKGROUND AND PURPOSE Proton (hydrogen-1 [(1)H]) MR spectroscopy is a useful diagnostic tool in many metabolic diseases, but only scattered and inconclusive data are available on mitochondrial diseases. We performed MR imaging and (1)H MR spectroscopy of the brain in patients with different types of primary mitochondrial diseases to investigate the role of (1)H MR spectroscopy in the clinical ...
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