Mycobacteria such as M. tuberculosis represent a significant health concern throughout much of the developing world. In mycobacteria and other pathogenic bacteria, an important virulence factor is the ability of the bacterium to obtain iron from its host. One means of obtaining iron is through the use of siderophores. Brasilibactin A is a membrane bound siderophore produced by Nocardia brasilie...

The sulfonated tripodal polyaza-polycatechol-amine ligand tris(2,3-hydroxy-5-sulfobenzylamine) ethyl)amine (STRENCAT) was synthesized and its protonation constants determined by potentiometry at 25 degrees C and in 0.1 mol dm(-3) NaClO(4). In the adopted experimental conditions (2.5 < p[H(+)] < 11.5), six of the virtual thirteen protonation constants of STRENCAT were determined. The deprotonati...

Physico-chemical profiling is a fundamental tool at the early stage of drug discovery in screening drug-like candidates. Complex physico-chemical profiling, including molecular properties such as solubility, ionization, lipophilicity and permeability, has been found to be of predictive power in ADME (absorption, distribution, metabolism, elimination). In the present thesis work, the physico-che...

A novel macrocyclic DO3A derivative containing a linear diamine pendant arm, H3do3aNN, was prepared and its protonation and complexation properties were studied by means of potentiometry. It determined ligand consecutive protonation constants log K(An) = 12.62, 10.28, 9.67, 8.30, 3.30 and 1.58 and stability constants of selected lanthanide (Eu(iii), Yb(iii)) complexes log K(EuL) = 23.16 and log...

ABSTRACT The stepwise protonation constants of two linear triphosphate ligand anions, triphosphate, [Formula: see text] and di-imidotriphosphate, [Formula: see text], were investigated by potentiometric titration, and the intrinsic chemical shifts of the stepwise protonated species of these anions were determined from the pH-dependence of the 31P NMR chemical shifts. All stepwise protonation co...

1H and 13C NMR measurements were carried out to explore anticipated correlations between chemical shifts versus thiolate basicities redox potentials of cysteamine, homocysteine, penicillamine, their homodisulfides. All analyzed statistically evaluated. The closest correlation was observed for the αCH nuclei concerning data. Since neither site-specific nor can be directly measured by any means i...

the determination of formation constants of binary inner transition metal complexes where m=y(iii) or la(iii) or ce(iii) or pr(iii) or nd(iii) or sm (iii) or gd (iii) or dy (iii) or th(iv) andl = creatinine have been carried out using irving–rossotti titration technique in aqueous mediaat different temperatures and at ionic strength. to understand more about the nature ofequilibrium involving i...