In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1-30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC) contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 microM), a CGRP1 receptor antagonist. These results indicate that in th...

Our understanding of the immediate effects of exercise on Achilles free tendon transverse morphology is limited to single site measurements acquired at rest using 2D ultrasound. The purpose of this study was to provide a detailed 3D description of changes in Achilles free tendon morphology immediately following a single clinical bout of exercise. Freehand 3D ultrasound was used to measure Achil...

Hot and cold water, in comparison to room temperature water, ingested by normal young men, profoundly alters esophageal motor function. Cold water slows or abolishes esophageal peristalsis, prolongs the contraction wave in the distal esophagus, produces a delayed but prolonged relaxation of the lower esophageal sphincter, and regularly causes a lower esophageal sphincteric contraction of increa...

we investigated contraction to noradrenaline (na) and kc1 and sensitivity of na at the level of larger vessels (thoracic aorta and vena cava; left renal artery and left renal vein; lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in w...

In this paper, we first give a new definition of Ω-Dedekind complete Riesz space (E,≤) in the frame vector metric (Ω,ρ,E) and investigate relation between Dedekind our concept. Moreover, introduce contraction so called α-vector proximal mapping. Then, prove certain best proximity point theorems for such mappings spaces where is space. Thus, time, acquire results on spaces. As result, generalize...

The main objective of this paper is to deal with some properties of interest in two types of fuzzy ordered proximal contractions of cyclic self-mappings T integrated in a pair (g, T) of mappings. In particular, g is a non-contractive fuzzy self-mapping, in the framework of non-Archimedean ordered fuzzy complete metric spaces and T is a p-cyclic proximal contraction. Two types of such contractio...

We consider the alternating proximal gradient method (APGM) proposed to solve a convex minimization model with linear constraints and separable objective function which is the sum of two functions without coupled variables. Inspired by Peaceman-Rachford splitting method (PRSM), a nature idea is to extend APGM to the symmetric alternating proximal gradient method (SAPGM), which can be viewed as ...

Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen receptor genes that are assembled by V(D)J recombination in immature B cells (Igh, Igk) and T cells (Tcrb, Tcra/d). V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) ...

The vastly enhanced spatial resolution of high-resolution manometry (HRM) makes it possible to simultaneous monitor contractile activity over the entire length of the esophagus. The aim of this investigation was to define the essential features of esophageal peristalsis in novel HRM paradigms and establish their normative values. Ten 5-ml water swallows were recorded in each of 75 asymptomatic ...