BACKGROUND Clinical tendon injuries represent serious and unresolved issues of the case on how the injured tendons could be improved based on natural structure and mechanical strength. The aim of this studies the effect of aquatic activities and alogenic platelet rich plasma (PRP) injection in healing Achilles tendons of rats. METHODS Forty rats were randomly divided into 5 equal groups. Seve...

PURPOSE The purpose of this study was to assess the effect(s) of platelet-rich plasma (PRP) on osteochondral donor site healing in a rabbit model. METHODS Osteochondral donor sites 3 mm in diameter and 5 mm in depth were created bilaterally on the femoral condyles of 12 New Zealand White rabbits. Knees were randomized such that one knee in each rabbit received an intra-articular injection of ...

OBJECTIVE Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT). DESIGN Prospective open label study with 1-year follow-up. METHODS Participants recruited from an outpatient sports medicine clinic had clinically and magnetic resonance image (MRI)-demonstrated RCT refractory to physical therapy and corticosteroid injection. They received one ultrasound-guided inject...

BACKGROUND Intra-articular injections of platelet-rich plasma (PRP) to treat symptoms of knee osteoarthritis (OA) have been successfully used in young patients and in the early stages of disease. No previous studies have analyzed outcomes of PRP injections during the late stages. HYPOTHESIS PRP reduces pain and leads to a more effective and lasting functional recovery than corticosteroid with...

OBJECTIVE To investigate whether the cartilage regenerative effects of intra-aricular platelet-rich plasma (PRP) are different, according to the severity of osteoarthritis (OA), in a collagenase-induced knee OA rabbit model. METHOD New Zealand white rabbits (N=21) were randomly divided into three groups. Three different doses (0.25 mg, group 1; 0.5 mg, group 2; and 1.0 mg, group 3) of collage...

Background: Wound healing follows a predictable course of overlapping phases, which involve cellular and biochemical events: (a) hemostasis and inflammation, (b) proliferation and (c) maturation and remodeling. Platelet Rich Plasma (PRP) is obtained by the blood from the patient being concentrated using different techniques. In the light of this basic information, platelet rich plasma (PRP) is ...

purpose: to report an idiopathic retinal vasculitis, aneurysm, neuroretinitis (irvan) case treated with one session of panretinal photocoagulation (prp) and intravitreal bevacizumab (avastin) case report: a 13-year-old boy was diagnosed as an irvan syndrome. systemic examination, fundus angiography, brain mri were performed to evaluate the patient. treatment with one session of prp, retinopexy ...

BACKGROUND Tendinopathy is very common in the general population. There are increasing numbers of clinical studies referring to platelet-rich plasma (PRP) and platelet-poor plasma (PPP) as treatments for tendinopathy. PURPOSE To perform a meta-analysis of the outcomes of the PRP groups by preparation method and injection technique in tendinopathy. To determine the clinical effectiveness of th...

Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate therapeutics for prion and Alzheimer's diseases. However, a previous report of severe and widespread apoptosis after intracerebral injection of anti-PrP monoclonal antibodies raised conc...