Plant innate immunity is mediated by pattern recognition receptors (PRRs) and intracellular NB-LRR (nucleotide-binding domain and leucine-rich repeat) proteins. Overexpression of the endoplasmic reticulum (ER) chaperone, luminal-binding protein 3 (BiP3) compromises resistance to Xanthomonas oryzae pv. oryzae (Xoo) mediated by the rice PRR XA21 [12]. Here we show that BiP3 overexpression also co...

The Renin-Angiotensin-Aldosterone System (RAAS) plays pivotal role not only in controling blood pressure or hydro-electrolyte balance but also in the pathogenesis of hypertension and renal diseases. Particularly, production of Reactive Oxygen Species (ROS) by increased angiotensinII (AngII) of the classical arm of RAAS is one of the important mechanisms in the pathogenesis of renal diseases. An...

Effects of low salt (LS) on (pro)renin receptor (PRR) expression are not well established. We hypothesized that LS enhances renal PRR expression via the cGMP-protein kinase G (PKG) signaling pathway. Sprague-Dawley rats were fed a normal-salt (NS) or LS diet associated with intrarenal cortical administration of vehicle (V), the nitric oxide (NO) synthase inhibitor nitro-l-arginine methyl ester ...

Our results showed that the parietal reach region (PRR) represents potential reaches (spatial location and effector) before an arm or eye movement is instructed or chosen (Cui and Andersen 2007, 2011), whereas area 5d only represents reaches (spatial location and effector) once a reach has been selected (Cui and Andersen 2011). We proposed that at the level of PRR, potential and chosen reaches ...

Angiotensin II (Ang II) stimulates (pro)renin receptor (PRR) expression in the renal collecting duct, triggering the local renin response in the distal nephron. Our recent study provided evidence for involvement of cyclooxygenase-2-prostaglandin E2 pathway in Ang II-dependent stimulation of PRR expression in the collecting duct. Here, we tested the role of E-prostanoid (EP) subtypes acting down...

Some potentially important findings from an analysis of 119,227 cancers registered in women in England over the 7-year period 1981 to 1987 are discussed. Data are presented for four cancer sites with established occupational etiologies (bladder, pleura, lung, larynx), three occupational groups in which women predominate (teachers, nurses, barstaff), and the main female cancers of the reproducti...

It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity. This paper first describes the expression of the vasoconstrictive arm...

Partial reconfiguration (PR) enables shared FPGA systems to nonintrusively time multiplex hardware tasks in partially reconfigurable regions (PRRs). To fully exploit PR, higher priority tasks should preempt lower priority tasks and preempted tasks should resume execution in any PRR. This preemption/resumption requires saving/restoring the preempted task’s execution context and relocating the ta...

Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differe...