BACKGROUND Human tissue kallikreins (KLKs) are a family of 15 trypsin-like or chymotrypsin-like secreted serine proteases (KLK1-KLK15). Multiple KLKs have been quantitatively identified in normal stratum corneum (SC) and sweat as candidate desquamation-related proteases. OBJECTIVES To quantify KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14 in the SC and serum of patients with psoriasis...

Psoriasis is a chronic skin disease associated with problems in body image and self-esteem and feelings of stigma and shame. The aim of this study was to analyse the clinical extent of psoriasis and its association with psychological distress, and to compare the psychopathological traits in early-onset (type I: age of onset < 40 years) vs. late-onset (type II: age of onset > 40 years) psoriasis...

Therapeutic agents with a putative anti-inflammatory mode of action are increasingly being pilot tested in psoriasis, a chronic inflammatory systemic disease. This is because the psoriasis patient contributes a number of advantages to trial design and execution (e.g., high disease prevalence, homogenous patient characteristics, skin manifestation that supports quick and easy quantification and ...

Multiple observational studies have demonstrated associations of psoriasis with metabolic syndrome including obesity, diabetes, hypertension, dyslipidemia, and osteoporosis. However there is paucity of Indian studies on dyslipidemia in psoriasis. The aim of this study was to assess the serum lipids in psoriasis and to investigate the association of lipids with disease severity and its duration....

Objectıves: Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the previous studies, left ventricul (LV) subclinical myocadial dysfunction was reported in the psoriasis patients. To evaluate the effect of psoriasis on left atrial (LA) functions, which is an important determinant left ventricular filling, atrial electromechanical coupling a...

BACKGROUND Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA). OBJECTIVES To assess bone and cartilage serum biomarkers in psoriasis. Methods. The study was conducted in 2014 and included 61 psoriatic patients and 30 healthy in...

OBJECTIVE To evaluate the association between different components of smoking history and the clinical severity of psoriasis. DESIGN A hospital-based cross-sectional study. SETTING Inpatient wards of a hospital for skin diseases in Rome, Italy. PATIENTS A total of 818 adults with psoriasis. MAIN OUTCOME MEASURE The Psoriasis Area and Severity Index was used to assess the clinical severi...

PURPOSE This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity. MATERIALS AND METHODS We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compar...

In the absence of any other lesions on the body, the diagnosis of localized genital psoriasis can be difficult, requiring further examinations including a biopsy. We report a case of psoriatic pseudobalanitis circinata triggered by a herpes virus infection, and we discuss the Koebner phenomenon and the therapeutic management of psoriasis of the genital area.

BACKGROUND Although nail psoriasis affects a marked proportion of patients with psoriasis and causes significant psychological stress, only few epidemiological data characterizing patients with nail involvement are available. OBJECTIVES To gain robust data on the epidemiology and disease burden of nail psoriasis in Germany. METHODS Two nationwide, noninterventional, cross-sectional studies ...