نتایج جستجو برای: pth1r

تعداد نتایج: 132  

Journal: :Cell metabolism 2017
Yi Fan Jun-Ichi Hanai Phuong T Le Ruiye Bi David Maridas Victoria DeMambro Carolina A Figueroa Serkan Kir Xuedong Zhou Michael Mannstadt Roland Baron Roderick T Bronson Mark C Horowitz Joy Y Wu John P Bilezikian David W Dempster Clifford J Rosen Beate Lanske

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption, and high bone marrow adipose tissue (BMAT). Bone marrow adipocytes traced to Prx1 and expressed classic adipogenic markers and high r...

2016
Natalie A. Sims

The recombinant parathyroid hormone (PTH) Teriparatide is the only therapy for postmenopausal osteoporosis that increases bone mass (i.e., is anabolic). Its therapeutic action depends on a short “burst” of PTH in the circulation followed by a rapid return to normal levels; if PTH levels remain high, bone loss occurs (i.e., the effect is catabolic) (Frolik et al., 2003). This occurs because PTH ...

Journal: :Oral 2022

Tooth eruption is a complex process, during which series of factors can cause failure it. Among this, primary (PFE) non-syndromic condition that leads to an incomplete tooth despite the presence clear pathway. The aim this narrative review provide overall view about clinical considerations, genetics-related aspects, and possible treatments PFE based on latest findings. A literature search using...

2010
Kiminori Yukata Chao Xie Tian-Fang Li Xinping Zhang Edward Schwarz

INTRODUCTION Aging decreases chondrogenesis, bone formation, callus vascularization and remodeling during facture healing in mice, which is associated with reduced cyclooxygenase-2 (COX-2) expression, and is restored by administration of an EP4 agonist. Activation of the EP4 receptor stimulates cAMP and activation of the protein kinase A (PKA) signaling pathway. These findings suggest that enha...

Journal: :American Journal of Orthodontics and Dentofacial Orthopedics 2017

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