Background: The aim of the study was to determine mechanism Moringa oleifera-induced apoptosis in HeLa cells. cells over-express cyclin E and B1, abrogate G0-G1 G2-M cell cycle arrest, promoting tumorigenesis. Cyclin E, E2F1 telomerase expression, caspase-3 -7 activation were assessed after 24-treatment with M. oleifera leaf fractions. Material methods: Apoptosis through caspase-7 determined qu...

We cloned cDNA encoding chicken cytoplasmic histone acetyltransferase-1, chHAT-1, comprising 408 amino acids including a putative initiation Met. It exhibits 80.4% identity to the human homolog and possesses a typical leucine zipper motif. The glutathione S:-transferase (GST) pull-down assay, involving truncated and missense mutants of the chicken chromatin assembly factor-1 (chCAF-1)p48, revea...

phlomis lanceolata is a medicinal plant that has long been used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. as most of phlomis species have shown cytotoxic activity against proliferation of different cell lines, a biological investigation of p. lanceolata was carried out in this study. the aim of this study was to find out the in vitro cyto...

background and objectives: colorectal cancer is the third most common cancer and a major cause of morbidity globally. hepatocellular carcinoma is a leading cause of death in the world. about 80% of all anticancer drugs are somehow related to natural products. one of the most important of these natural compounds is curcumin, the main component of turmeric that has a wide range of pharmacological...

background: during the past few years, hesa-a, a herbal-marine mixture, has been used to treat cancer as an alternative medicine in iran. however, weight of the evidence is not sufficient to accept or refuse the use of this compound as a cytotoxic drug. we investigated the selective anticancer effects of hesa-a on breast, prostate, colon, and glioblastoma multiforme (gbm) neoplastic cell lines....

introduction: in orthodontic therapy ,different materials are used and their presence in oral cavity may modify their properties. the purpose of this study was to evaluate the direct and indirect biocompatibility of three orthodontic composite resins on culture of human oral fibroblasts. methods: this was an interventional experimental study. the biocompatibility of three orthodontic composite ...

objective(s): several beneficial effects have been attributed to the probiotic lactic acid bacteria. it was determined that lactobacilli can exert antiproliferative effects on the various cancer cell lines including colon cancer. effects of lactic acid bacteria on colon cancer may vary from strain to strain and there is a need to find the new probiotic strains with tumor suppressing properties ...

introduction: root canal disinfection is an important step in regenerative endodontic treatments. an ideal irrigating solution must have high antimicrobial activity and minimum cytotoxicity. this study sought to assess the effect of some irrigating solutions on stem cells from the human apical papilla (scap) after different periods of exposure. methods and materials: stem cells were isolated fr...