MEASUREMENT of pulmonary vascular resistance has frequently been used in the study of vasoactive drugs to indicate changes in pulmonary vascular tone.' However, as pointed out by Borst et al. 4 and Fowler, it is not possible in many of these studies to separate vasoactive drug effects from purely mechanical effects resulting from changes in transmural pressure,* and lung volume. It is the purpo...

MEASUREMENT of pulmonary vascular resistance has frequently been used in the study of vasoactive drugs to indicate changes in pulmonary vascular tone.' However, as pointed out by Borst et al. 4 and Fowler, it is not possible in many of these studies to separate vasoactive drug effects from purely mechanical effects resulting from changes in transmural pressure,* and lung volume. It is the purpo...

A 42-year-old woman presented with a huge benign pelvic tumour and recurrent pulmonary emboli associated with severe microangiopathic haemolytic anaemia (MAHA). Following removal of the tumour and anticoagulation, all signs of MAHA disappeared. MAHA may occur when red blood cells pass through abnormal blood vessels in tumours. This patient is unusual in that the tumour was benign, rather than m...

BACKGROUND Chronic obstructive pulmonary disease causes significant morbidity and concomitant pulmonary vascular disease and cardiac dysfunction are associated with poor prognosis. Computed tomography-detected relative pulmonary artery (PA) enlargement defined as a PA to ascending aorta diameter ratio >1 (PA:A>1) is a marker for pulmonary hypertension and predicts chronic obstructive pulmonary ...

  Pulmonary agenesis is a rare congenital anomaly in which there is absence of pulmonary parenchyma as well as its bold vessels. It is an unusual cause of respiratory distress in newborn. Unilateral agenesis of lung is often associated with other congenital anomalies. The condition may lead to diagnostic difficulties.   Right pulmonary agenesis has poor prognosis. Here we present a case of fem...

MRI images of pulmonary blood flow using arterial spin labeling (ASL) measure the delivery of magnetically tagged blood to an image plane during one systolic ejection period. However, the method potentially suffers from two problems, each of which may depend on the imaging plane location: 1) the inversion plane is thicker than the imaging plane, resulting in a gap that blood must cross to be de...

THE MAMMALIAN VASCULATURE develops by a process called vasculogenesis in which the differentiation and proliferation of endothelial precursor cells leads to formation of tubes that comprise the primary vascular plexus. Subsequent remodeling of the primary vascular plexus by a process called angiogenesis leads to the formation of the highly branched hierarchical vascular tree consisting of arter...