Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis...

Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent modulators of immune cell responses and cytokine re...

Purine nucleotides serve as immediate building blocks for the synthesis of RNAs and DNA, energy carriers co-substrates in activation many metabolites, regulators cellular metabolism, signaling molecules. Knowledge actual tissue-specific concentration these metabolites their rate is essential to studies focused on a metabolic rewiring pathogenesis different diseases, including carcinogenesis. Th...

Alkylating agents have been studied extensively both for their biological effects and for their mode of action. There have been over the past 25 years a veritable deluge of reviews, often focusing on a single aspect or agent or adduct. It can be easily noted that certain analytical techniques were widely used. These were either neutral heating of DNA which liberates 3and 7alkyl purines and/or h...