Abstract This study intended to optimize apigenin (APG) nanoparticle formulation prepared by planetary ball milling enhance its dissolution rate and bioavailability using a design of experiment (DoE). In this study, polyvinyl pyrrolidone (PVP K30) was used as stabilizer. The independent parameters speed, size, drug solvent ratio were evaluated for their impacts on APG nanoparticles concerning t...

Aim: This work aims to develop oral disintegrating tablets from solid dispersion of aripiprazole that are capable enhancing solubility.
 Methodology: Aripiprazole an antipsychotic is a BCS class IV drug with Oral bioavailability 87%. To enhance the solubility this dispersions were prepared by using combination ?-Cyclodextrin and PVP K30 in 1:1, 1:2 physical mixture solvent evaporation meth...

Abstract: Aim: The present work intends to formulate and evaluate film forming solution of diphenhydramine. Materials Methods: Film solutions (FFS) for transdermal delivery Diphenhydramine HCl were prepared using different polymers (hydroxypropyl cellulose, Eudragit L 100, polyvinylpyrollidone K30 K90), PEG 400 as plasticizer ethyl alcohol solvent. Results: found display an acceptable drying ti...

A Novel floating controlled release drug delivery system of famotidine was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. The present work investigates the approach using two different polymers HPMC K100 M and natural polymer Chitosan . A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicar...

The present study was aimed to develop the Glimepiride (GLM) loaded nanosuspension by different methods for increasing solubility of GLM. Twelve formulations were prepared combination method (FG), which included antisolvent precipitation followed sonication (Method 1) selecting drug and polymer in ratio 1:10, 1:20 1:30. Further 6 nanoprecipitation (Fg) 2) using polymers like polyvinyl pyrolidon...

For almost two hundred years, diabetes mellitus has been a major health problem worldwide. While there progress in our knowledge of its pathophysiology and treatment, the therapeutic choices available today are woefully inadequate. The goal transdermal medication delivery systems is to provide therapeutically effective doses medicine via skin. released at steady, regulated pace thanks design th...

Curcumin là hợp chất tự nhiên được chứng minh có nhiều hoạt tính sinh học khác nhau như kháng khuẩn, oxy hóa và tế bào ung thư. Tuy nhiên, của curcumin thấp do ít tan trong nước tốc độ phân hủy cao. Trong nghiên cứu trước, viên nang kích thước micro đã chế bằng phương pháp tạo gel ion. Nghiên này tiếp tục kiểm khả năng hòa ổn định Solutol HS 15 một số động bề mặt khác. Kết quả cho thấy, đạt giá...

The objective of the present investigation was to develop a bilayer-floating tablet (BFT) for captopril using direct compression technology. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. The floa...