......................................................................................................................................... ii Abbreviations and Atom Colour Scheme .................................................................................... iii Chapter 1: Introduction .............................................................................................................

In the last decades a number of pyrazole and isoxazole derivatives have been introduced in clinical practice. The therapeutic effectiveness of these agents has been bounded by a number of limiting factors. Due to this, the development of novel, selective, potent and safe agents remains in high priority in medicinal chemistry research. Synthans, such as oxoketenedithioacetals are known in the li...

Accumulating evidence suggests that deposition of neurotoxic a-synuclein aggregates in the brain during the development of neurodegenerative diseases like Parkinson’s disease can be curbed by anti-aggregation strategies that either disrupt or eliminate toxic aggregates. Curcumin, a dietary polyphenol exhibits anti-amyloid activity but the use of this polyphenol is limited owing to its instabili...

Aromatic organic heterocycle containing pyrimidine scaffolds possesses two nitrogen atoms of Five-membered ring. These Pyrazole skeletons comprise various ranges of pharmacological activities such as analgesic, antipyretic, anticancer, antiviral, anti-inflammatory, antioxidants, antimicrobial, anti-diabetic, anticonvulsant, ant arrhythmic activities. Pyrazole is a multipurpose lead compound dev...

In the title compound, C(26)H(20)BN(3)O, the B atom has tetra-hedral geometry and is linked to two phenyl rings, the O atom of the hy-droxy-pyrazole ring and the N atom of the pyridinyl ring. A six-membered BOCNCN ring forms by coordination of the B atom and the pyridinyl N atom. The BOCNCN ring has an envelope conformation [dihedral angle = 36.7 (1)° between the planar ring atoms and the flap]...

In the past decade, lanthanoid coordination chemistry was one of most focused areas research due to their wide applications as catalyst, magnetism, luminescence and diagnostic tools in biological studies. this study, novel pyrazole; 5-((2-phenylacetoxy) carbonyl)-1Hpyrazole-3-carboxylic acid derivative its complexes are designed tested for potential antimicrobial antimalarial activities. The bi...

Abstract Organic syntheses by adopting green protocols such as sonochemical procedures, microwave technologies, solvent-free conditions, solvent, heterogeneous catalysis particularly nanocatalysts, ionic liquids have replaced the traditional procedures due to concerns pertaining especially environment. The heterocycle, pyrazole, its multifaceted applications has been cyanosure of chemists and t...

The remarkable prevalence of pyrazole scaffolds in a versatile array bioactive molecules ranging from apixaban, an anticoagulant used to treat and prevent blood clots stroke, bixafen, pyrazole-carboxamide fungicide control diseases rapeseed cereal plants, has encouraged both medicinal organic chemists explore new methods developing pyrazole-containing compounds for different applications. Altho...

In the title compound, C(29)H(29)N(5), the central pyridine ring and the two pyrazole rings are approximately coplanar, the dihedral angles between the pyridine and pyrazole rings being 3.94 (12) and 14.84 (12)°. The pyrazole and phenyl rings on each side of the mol-ecule are twisted with dihedral angles of 46.72 (8) and 73.39 (8)°. One phenyl ring inter-acts with a pyrazole ring of a neighbour...

Potential energy surfaces of N,N-hydrogen migration of pyrazole and 5-methyl pyrazole for the ground and triplet states were calculated by the ab initio molecular orbital methods. All potential energy surfaces for the N.N-hydrogen shift have high energy barriers. The occurrence of the structural change indispensable to the switching function is doubtful for pyrazole and 5-methyl pyrazole. The s...