Sport and leisure horses in Morocco are treated with several anthelmintics, organophosphates (dichlorvos), benzimidazoles (mostly thiabendazole) or tetrahydropyrimidines (mostly pyrantel pamoate) against nematodes. We studied three horse stables in Rabat, one in Meknes and one in Bouznika. Two of the Rabat and Bouznika stables had introduced a large number of horses from countries (Argentina or...

The evolutionarily conserved Wnt signaling pathway provides temporal and spatial cues during early embryonic development and during homeostatic function of numerous adult tissues [1]. Wnt signaling also drives the onset and progress of a broad array of human cancers, including nearly all nonhereditary colorectal cancers (CRCs) [1]. Despite the importance of this pathway in cancer, no Wnt inhibi...

A number of porous salts based on the pamoate anion in combination with lutidinium or picolinium cations have been characterised. One salt undergoes single-crystal to single-crystal solvent exchange, while another isostructural series of salts contain channels that can be partly evacuated without collapse of the framework.

Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible for the pharmacological effect are unknown. We assessed the distribution and uptake of albendazole, albendazole sulfoxide, albendazole sulfone in ...

There are few reports in the dental literature of the use of morphine sulfate in sedating a child. The findings of this 9-year study using morphine sulfate and hydroxyzine pamoate for the treatment of apprehensive and fearful children justify further investigation into its use. A total of 4363 uses of the agents were recorded between July, 1975, and June, 1984. Where any abnormal response to th...

inhibition of the oncogenic activation of signalling pathways represents the main goal of drug discovery in oncology. Selective inhibitors of oncogenes such as mutated kinases and phosphatases have been identified mainly through traditional small molecule drug screenings aimed at identifying inhibitors of catalytic activity. However, ever-increasing failure rates, high costs, unsatisfactory saf...

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characteristic that was highly conserved among cancer stem cells, across multiple tumor types, to provide a mutation-independent approach to cancer therapy...