STUDY OBJECTIVE In COPD, it has been shown that peripheral muscle dysfunction is a factor determining exercise intolerance. We examined the hypothesis that exercise capacity of patients with idiopathic pulmonary fibrosis (IPF) is, at least in part, determined by peripheral muscle dysfunction. METHODS Maximum oxygen uptake (V(O2)max) was evaluated in 41 consecutive patients with IPF, along wit...

OBJECTIVE To analyse the results of the first 2 years of a QF-PCR stand-alone testing strategy for the prenatal diagnosis of aneuploidy in the London region and to determine the advantages and disadvantages of this policy. METHODS A review of the results of 9737 prenatal samples received for exclusion of chromosome abnormalities. All samples were subjected to QF-PCR testing for common aneuplo...

BACKGROUND Despite being deliberately targeted to common chromosome aneuploidies, the rapid quantitative fluorescent polymerase chain reaction (QF-PCR) tests can detect the majority of chromosome abnormalities in prenatal diagnosis. The main advantages of this assay are low cost, speed and automation allowing large-scale application. METHODS We developed a QF-PCR test that was applied on 43 0...

A discrete electrostatic/diffusion model has been developed to describe the selective permeation of ion channels, based on ionic Coulomb blockade (ICB) and quantised dehydration (QD). It has been applied to describe selectivity phenomena measured in the bacterial NaChBac sodium channel and some of its mutants. Site-directed mutagenesis and the whole-cell patch-clamp technique were used to inves...

This study tested the hypothesis that fatigue of a single member of musculus quadriceps femoris (QF) would alter use of the other three muscles during knee extension exercise (KEE). Six men performed KEE with the left QF at a load equal to 50% of the 4 x 10 repetitions maximum. Subsequently, electromyostimulation (EMS), intended to stimulate and fatigue the left m. vastus lateralis (VL), was ap...

The Teichmüller space Teich(S) of a surface S in genus g > 1 is a real submanifold of the quasifuchsian space QF(S). We show that the determinant of the Laplacian det′(∆) on Teich(S) has a unique holomorphic extension to QF(S).

Th e syndrome qf inappropriate secretion qf antidiuretic hormone (S IADH) is a common medical illness which has many etiologies-some ofwhich are particular to psychiatric pat ients. Th is review will discuss the diagnosis qfSIADH and then the various etiologiesfor its development wi th emphasis on those which are more relevant to psychiat ric patients. Future research will be directed to afu rt...