although many methods exist for intensity modulated radiotherapy (imrt) fluence map optimization for crisp data, based on clinical practice, some of the involved parameters are fuzzy. in this paper, the best fluence maps for an imrt procedure were identifed as a solution of an optimization problem with a quadratic objective function, where the prescribed target dose vector was fuzzy. first, a d...

PURPOSE To describe a multiplan intensity-modulated radiotherapy (IMRT) planning framework, and to describe a decision support system (DSS) for ranking multiple plans and modeling the planning surface. METHODS AND MATERIALS One hundred twenty-five plans were generated sequentially for a head-and-neck case and a pelvic case by varying the dose-volume constraints on each of the organs at risk (...

Cigarette smoking is associated with an increased risk of leukemia; benzene, an established leukemogen, is present in cigarette smoke. By combining epidemiologic data on the health effects of smoking with risk assessment techniques for low-dose extrapolation, we assessed the proportion of smoking-induced total leukemia and acute myeloid leukemia (AML) attributable to the benzene in cigarette sm...

Peripubertal beef heifers (n = 57) and postpartum multiparous cows (n = 52) were used to determine the optimal dose of estradiol benzoate (EB) to induce and synchronize estrus after treatment with intravaginal progesterone inserts (IVP4, EAZI-BREED CIDR) . All females received an IVP4 for 7 d (d 0 = insertion day) with a 25-mg injection of PGF2a (Lutalyse) on d 6. At 24 to 30 h after IVP4 re...

Carcinogenesis data for 315 chemicals were obtained from the National Cancer Institute-National Toxicology Program (NCI-NTP) bioassay programs and were analyzed to examine the shape of carcinogenesis dose-response curves. Tumor site data were more often consistent with a quadratic response than with a linear response, suggesting that the routine use of linear dose-response models will often ove...

The aim of this research was to study the in vitro effect of Lavandula officinalis (LEO) and Origanum vulgare (OEO) essential oils on rumen fermentation using a concentrate type substrate (CTS) and roughage type substrate (RTS). Six Mehraban ewes were divided into 2 groups and fed a concentrate type or roughage type diet, and used as rumen fluid donors. Each essential oil (EO) was evaluated sep...

Recent technological advances enable radiation therapy to be delivered in a highly conformal manner to targets located almost anywhere in the body. This capability has renewed the clinical interest in hypofractionation wherein the tumor is delivered a few fractions of very large dose per fraction. Extrapolating clinical experience from conventional regimens to fractions of high dose is importan...

The cytogenetic effect of low-dose gamma irradiation on the heredity structures of rabbits was studied. Rabbit peripheral blood lymphocytes were irradiated in vitro within the dose range 0.25-1.0 Gy on Rokus equipment with Со radiation source at a dose rate of 2.22 cGy/s. The analysis of cytogenetic data showed that the frequency of induced chromosomal aberrations in rabbit peripheral blood lym...