This study examined the effects of quercetin on spontaneously contracting portal veins isolated from healthy young adult male and female Wistar rats (250-300 g). Quercetin (10(-7)-10(-4) M) always produced significant biphasic effects, comprising an initial brief stimulant effect (rise in basal tone), followed by a sustained, longer-lasting secondary relaxant (inhibitory) effect on the venous t...

The dietary flavonoid quercetin reduces blood pressure and improves endothelial function in several rat models of hypertension. We analyzed the effects of quercetin and its methylated metabolite isorhamnetin on the aortic endothelial dysfunction induced by incubation with angiotensin II (AngII) in vitro for 6 h. AngII diminished the relaxant responses to acetylcholine in phenylephrine-contracte...

BACKGROUND This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine. METHODS 32 adult male Wistar rats were randomly divided into 4 groups fed normal diet, normal diet with quercetin supplementation (25 mg/kg·BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation. All rats were sacrificed ...

introduction: dark neurons which their morphological characteristics are consistent with those of cells undergoing apoptosis, are generated as an acute or delayed consequence of several pathological situations. the present study was designed to evaluate whether inflammatory pain regarding the role of no and jnk lead to the formation of dark neurons in the dorsal horn of the lumbar spinal cord i...

Vascular complications are the leading cause of morbidity and mortality in patients with diabetes. Quercetin is an important flavonoid with antioxidant and anti-inflammatory activity. Here, the effect of quercetin on diabetes-induced exaggerated vasoconstriction in insulin deficient and insulin resistant rat models was investigated. Insulin deficiency was induced by streptozotocin while, insuli...

In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially...

Program Scope Clathrate hydrates are inclusion compounds in which guest molecules occupy the cages formed by a hydrogen-bonded water network [1]. Solid gas clathrate hydrates generally form at high pressures and temperatures near or even above the ice point. Pure hydrogen hydrates have been reported to form cubic structure II hydrates under extreme conditions (200 MPa at 280 K) [2]. We have rec...

Rapid and eco-friendly preparation of biomedical materials is significant for practical applications. This study proposes a simple two-step method preparing silver nanoparticles (AgNPs)-functionalized gauze dressings (Ag-Q-G) with antibacterial activity in green time-efficient manner that requires <10 min. A smooth uniform quercetin coating formed on the fibers using alkali–acid redeposition 10...

Solid gas hydrates are a potentially huge resource of natural gas for the United States. The U.S. Geological Survey estimated that there are about 85 trillion cubic feet (TCF) of technically recoverable gas hydrates in northern Alaska. The Minerals Management Service estimated a mean value of 21,000 TCF of in-place gas hydrates in the Gulf of Mexico. By comparison, total U.S. natural gas consum...