I n my Presidential Address in June of 1998 (1), I proudly announced that the most recent Five Year Plan adopted by the American Diabetes Association contained the goal of allocating one of every three dollars of total public support to research awards and grants by the end of 5 years. I pledged to keep the members of the professional section apprised of our progress toward that goal. The gener...

OBJECTIVE To validate fasting indices of insulin sensitivity and secretion in a diverse pediatric population against gold standard estimates from euglycemic and hyperglycemic clamps. RESEARCH DESIGN AND METHODS A total of 31 children (mean BMI 25.1 +/- 4.9 kg/m(2), mean age 8.7 +/- 1.4 years, 15 girls and 16 boys, 12 black and 19 white) underwent euglycemic and hyperglycemic clamps 2-6 weeks ...

BACKGROUND AND OBJECTIVES Undiagnosed diabetes mellitus (DM) or impaired glucose tolerance (IGT) is not uncommon in patients with coronary atherosclerosis and is known to be associated with abnormal scores for atherosclerosis surrogates. We sought to determine the prevalence of undiagnosed DM or IGT, and the association between insulin resistance (IR) and atherosclerosis surrogates in patients ...

BACKGROUND/OBJECTIVES Insulin resistance (IR) and hypertension are common in overweight children, and the adipocyte-derived hormones resistin, adiponectin, and leptin may modulate IR and blood pressure (BP). Few data exist in children on dietary determinants of IR, BP, or leptin, and no data exist on dietary determinants of resistin and adiponectin. Therefore, the objective of this study was to...

BACKGROUND The aim of this study was to assess the possible associations between female androgenetic alopecia (AGA), insulin resistance and health-related quality of life (HRQOL)-linked factors in women. We hypothesized that not only the mental aspects but also certain physical aspect of women's health, such as insulin resistance, have an important role in the determination of HRQOL among women...

Abstract Context Insulin resistance (IR) and abnormal insulin secretion play a key role for the development of type 2 diabetes mellitus (DM). Aims We investigated surrogate markers IR, i.e., Homeostasis Model Assessment (HOMA), Quantitative Sensitivity Check Index (QUICKI), McAuley, Fasting Resistance (FIRI) in DM patients. Also, fasting (FI) levels were estimated diabetics. Further, correlatio...

conclusions the mathematical meaning of the two insulin-related biomarkers examined was the same, and the odds ratios of the two biomarkers were almost the same after adjustments for other independent variables. objectives a one-year follow-up study was conducted to determine the ability of the insulin-related biomarkers to predict the risk of mets development. patients and methods a total of 2...

CONTEXT The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition. OBJECTIVE Our aim was to study the skeletal muscle hormone irisin in HP, and compare the results with a similar group of normal subjects. PARTICIPANTS AND MET...

Purpose: Determine if three weeks of HIT (high-intensity interval training) improves fasting insulin sensitivity in healthy males. Methods: Participants were recreationally active ( ≥ 10 hours per week) men between 18 and 35 years of age (Ht: 180 ± 1.44 cm; Wt: 85 ± 2.95 kg; BMI: 26.1 ± 0.59 kg/m2; body fat: 19.7 ± 1.76%). HIT training occurred 3 days weekly for 3 weeks, at intensities equivale...