Antineoplastic intercalating agents such as 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) stabilize a cleavable complex between topoisomerase II and DNA. The production of protein-associated DNA cleavage in whole cells exposed to m-AMSA is thought to represent the cellular correlate of this topoisomerase II-mediated reaction. Protein-associated DNA cleavage can be quantified in mammal...

ABSTRACT We identify the first quiescent galaxies in TNG300, largest volume of IllustrisTNG cosmological simulation suite, and explore their quenching processes time evolution to z = 0. find that with stellar masses M* > 3 × 1010 M⊙ specific star formation rates sSFR < 10−11 yr−1 emerge at ∼ 4.2 TNG300. Suppression these begins a thermal mode active galactic nucleus feedback 6, ki...

Abstract Forecasts of eruption are uncertain. The uncertainty is amplified when volcanoes reawaken after several generations in repose, because direct evidence previous behaviour rarely available. It fosters scepticism about warnings volcanic activity and may compromise the success emergency procedures. quality forecasts has improved over past 50 years, owing mainly to a growing sophistication ...