A dual catalytic system consisting of indium triflate and a chiral imidazolidinone catalyzes the asymmetric addition of aldehydes to N-acyl quinoliniums furnishing optically active dihydroquinolines in good yields and excellent selectivities. The products were further functionalized into optically active tetrahydroquinolines, quinolines and 6-oxa-2-aza-bicyclo[3.3.1]nonanes.

The 'template' polyborate BOROX catalysts are shown to mediate the asymmetric transfer hydrogenation of 2-quinolines. The rapid and simple generation of a large family of BOROX catalysts with significantly altered asymmetric pockets is described. A transition state model that explains the enantioselectivity is proposed.

Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed by an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl-metal species, which then rearranges selectively by careful choice of cat...

1,1-Cyclopropane aminoketones were efficiently synthesized in high yields by the tandem reaction of α-amino aryl ketones with vinyl sulfonium salts using DBU as the base in CH(2)Cl(2). This methodology was utilized to synthesize 2-benzoyl quinolines.

Pain is a widely spread symptom and one of the most common causes making people seek medical attention. Though at present, different methods of pain control such as general narcosis, acupuncture, hypnosis, electroanaesthesia, homeopathy, etc., are known, nothing is better for safety and reliability than local anaesthesia. More often it is an effective alternative to general narcosis and promote...

a simple and efficient method for the synthesis of quinolines and polycyclic quinolines using li+ modified nanoporous na+-montmorillonite is described. this new nanocatalyst proceeds via friedlander annulation under solvent-free conditions. it describes our observations about a trend of catalytic activity of lithium cation in nanoporous na+-montmorillonite. in this study, several types of 1,3-d...

2-amino-substituted ketones react with α-methylene ketones under solvent-free conditions at 90 °c in thepresence of a catalytic amount of zirconium dodecylphosphonate to create the corresponding quinolinesin excellent yields. this procedure recommends numerous advantages such as easy work-up, use of mild,reusable and safe catalyst, short reaction timeand high yields. the new compounds have been...

The quinoline fused-ring system of the title compound, C(11)H(8)ClNO, is planar (r.m.s. deviation = 0.005 Å); the formyl group is slightly bent out of the plane [C-C-C-O1 torsion angles = 8.8 (7) and -172.8 (4)°].

The quinoline fused-ring system of the title compound, C(11)H(8)ClNO(2), is planar (r.m.s. deviation = 0.0095 Å); the formyl group is slightly bent out of this plane [C-C-C-O torsion angles = -2.4 (3) and 175.9 (2)°].