Background Measurement of the myocardial extracellular volume fraction (ECV) assumes a dynamic equilibrium with rapid exchange of an extracellular contrast agent between myocardium and blood. This equilibrium would be manifested by a linear relationship between 1/T1 (R1) of myocardium and 1/T1* (R1*) of blood. This relationship has been shown to be non-linear for high R1 values in mice, and thi...

Rhesus monkey rhadinovirus (RRV) is a gamma-2 herpesvirus that is most closely related to the human Kaposi's sarcoma-associated herpesvirus (KSHV). We have identified a distinct open reading frame at the left end of RRV and designated it R1. The position of the R1 gene is equivalent to that of the saimiri transforming protein (STP) of herpesvirus saimiri (HVS) and of K1 of KSHV, other members o...

Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by cytosolic calcium (Ca(2+)) plays an essential role in their signaling function, but structural determinants and mechanisms responsible for the InsP(3)R1 regulation by Ca(2+) are poorly understood. Using DT40 cell expression system and Ca(2+) imaging assay, in our previous study we identified a critical role of E210...

The vocal tract resonances of trained soprano singers were measured while they sang a range of vowels softly at different pitches. The measurements were made by broad band acoustic excitation at the mouth, which allowed the resonances of the tract to be measured simultaneously with and independently from the harmonics of the voice. At low pitch, when the lowest resonance frequency R1 exceeded f...

Microtubule nucleation on the centrosome and the fungal equivalent, the spindle pole body (SPB), is activated at the onset of mitosis. We previously reported that mitotic extracts prepared from Xenopus unfertilized eggs convert the interphase SPB of fission yeast into a competent state for microtubule nucleation. In this study, we have purified an 85-kDa SPB activator from the extracts and iden...

In this paper, we give a short survey on discrete geometry on red and blue points in the plane, most of whose results were obtained in the past decade. We consider balanced subdivision problems, geometric graph problems, graph embedding problems, Gallai-type problems and others. 1 Notation and Definitions In this paper, we give a short survey on discrete geometry on red and blue points in the p...

Comparative analysis of development and survivorship of two geographically divergent populations of the Natal fruit fly Ceratitis rosa Karsch designated as Ceratitis rosa R1 and Ceratitis rosa R2 from Kenya and South Africa were studied at seven constant temperatures (10, 15, 20, 25, 30, 33, 35 °C). Temperature range for development and survival of both populations was 15-35 °C. The development...

OBJECTIVE This study evaluated the possibility of accelerated gadolinium accumulation in irradiated brain parenchyma where the blood-brain barrier was weakened. METHODS From January 2010 to June 2015, 44 patients with supratentorial glioblastoma were retrospectively identified who underwent pre- and post-radiation brain MR imaging, including R1 mapping. The mean dose of administered gadobutro...

OBJECTIVE To compare long-term outcome of R0 (negative margins) and R1 (positive margins) liver resections for colorectal liver metastases (CLM) treated by an aggressive approach combining chemotherapy and repeat surgery. SUMMARY BACKGROUND DATA Complete macroscopic resection with negative margins is the gold standard recommendation in the surgical treatment of CLM. However, due to vascular p...

The edge-to-edge repair (EtER) technique was introduced in 1991 to treat both mitral regurgitation (1) and tricuspid regurgitation (2) caused by complex valvular lesions. The method involves anchoring the free edge of the diseased leaflet to the corresponding edge of the opposing leaflet, just at the place of the regurgitant jet. When the middle sections of the leaflets are sutured, a ‘double-o...