One of the fundamental problems in neuroscience today is to understand how the activation of large populations of neurons gives rise to the higher order functions of the brain including learning, memory, cognition, perception, action and ultimately conscious awareness. Electrophysiological recordings in behaving animals over the past forty years have revealed considerable information about what...

OBJECTIVES To review the evidence for the efficacy and safety of biological agents in patients with rheumatoid arthritis (RA) to provide data to develop treatment recommendations by the European League Against Rheumatism (EULAR) Task Force. METHODS Medline, Embase and Cochrane databases were searched for relevant articles on infliximab (IFX), etanercept (ETN), adalimumab (ADA), certolizumab-p...

The cations and anions of the chiral title compound, C(5)H(14)N(2) (2+)·2Cl(-)·0.42H(2)O, are linked by N-H⋯Cl hydrogen bonds into chains propagating in [100], which contain R(4) (2)(14) loops.

OBJECTIVE To review published cases of induced or exacerbated interstitial lung disease (ILD) in rheumatoid arthritis (RA) associated with non-biologic disease-modifying antirheumatic drugs (nbDMARDs) and biologics and to discuss clinical implications in daily practice. METHODS We performed a systematic literature review from 1975 to July 2013 using Medline, Embase, Cochrane, and abstracts fr...