The aim of the present study was to assess recovery from hematopoietic and gastrointestinal damage by Ex-RAD(®), also known as ON01210.Na (4-carboxystyryl-4-chlorobenzylsulfone, sodium salt), after total body radiation. In our previous study, we reported that Ex-RAD, a small-molecule radioprotectant, enhances survival of mice exposed to gamma radiation, and prevents radiation-induced apoptosis ...

Vaccines harboring genes that encode functional oncoproteins are intrinsically hazardous, as their application may lead to introduction of these genes into normal cells and thereby to tumorigenesis. On the other hand, oncoproteins are especially attractive targets for immunotherapy of cancer, as their expression is generally required for tumor growth, making the arisal of tumor variants lacking...

Národní ?asopisy jsou d?ležitým prost?edkem pro p?stování dialogu o sm??ování jednotlivých obor?. ?lenové redak?ních rad t?chto ?asopis? mohou ovlivnit kodifikaci m??ítek prací publikovaných v daném oboru, bývají proto ozna?ováni jako gatekeepers, tedy „strážci brány vybírající, který obsah a forma v?deckého sd?lení p?ijatelné“. Abychom si vytvo?ili alespo? p?ibližnou p?edstavu složení rad, m?ž...

Let A be a finite-dimensional, basic, connected algebra over an algebraically closed field. Denote by Γ (A) the Auslander–Reiten quiver of A. We show that A is representation-finite if and only if Γ (A) has at most finitely many vertices lying on oriented cycles and finitely many orbits with respect to the action of the Auslander–Reiten translation. Let K denote a fixed algebraically closed fie...

Activation of D4 receptors (D4Rs) has been shown to improve cognitive performance, potentially affecting synaptic strength. We investigated the D4R agonist PD 168077 (PD) in hippocampal CA1 of freely moving mice. We electrically stimulated in stratum oriens (OR) or radiatum (RAD) and evoked local field potentials (LFPs). Intraperitoneally injected PD dose-dependently and reversibly attenuated L...

In this paper, we introduce the concept of a quasi-radical semi prime submodule. Throughout work, assume that is commutative ring with identity and left unitary R- module. A proper submodule called (for short Q-rad-semiprime), if for , ,and then . Where intersection all submodules

we consider the class $mathfrak m$ of $bf r$--modules where $bf r$ is an associative ring. let $a$ be a module over a group ring $bf r$$g$, $g$ be a group and let $mathfrak l(g)$ be the set of all proper subgroups of $g$. we suppose that if $h in mathfrak l(g)$ then $a/c_{a}(h)$ belongs to $mathfrak m$. we investigate an $bf r$$g$--module $a$ such that $g not = g'$, $c_{g}(a) = 1$. we stud...