BACKGROUND AND PURPOSE Apoptotic-like pathways may contribute to brain cell death after intracerebral hemorrhage. In this study, we used a simplified in vitro model of hemoglobin neurotoxicity to map the caspase cascades involved and to document the role of oxidative stress. METHODS Primary neuronal cultures were obtained from rat cerebral cortex and exposed to hemoglobin to induce cell death...

Oxidative damage that results in lipid peroxidation can inactivate cellular components and can have serious effects on the cells, probably leading to ageing as well as several diseases. In recent years much attention has been focused on this subject, especially in the field of clinical medicine. Several natural compounds from plants exhibit antioxidant and/or radical scavenger properties. It al...

The oxidative stress causes many diseases in human, therefore antioxidants have a special position in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty of biological properties. There are many strategies such as clustering single drug units in order to develop new drugs. The cluster effect can increase drug effects relative to single drug unit. Calixtyrosol is the novel...

Colorectal Cancer (CRC) is among the most common types of cancer in world. Globally a steadily increasing proportion elderly people world result approximately 16 million new cases by year 2021. Regarding treatment; Meloxicam was shown to prevent initiation chemical-induced tumors, and considered as anticancer agent virtue its anti-proliferative effect, capacity for cell cycle arrest, pro-apopto...

Benzene, a known human myelotoxin and leukemogen is metabolized by liver cytochrome P-450 monooxygenase to phenol. Further hydroxylation of phenol by cytochrome P-450 monooxygenase results in the formation of mainly hydroquinone, which accumulates in the bone marrow. Bone marrow contains high levels of myeloperoxidase. Here we report that phenol hydroxylation to hydroquinone is also catalyzed b...