Pharmacokinetic parameters are important for calculating the absorbed dose; they also provide an indirect measure of in vivo stability a radiopharmaceutical. The aim study was to determine excretion rate activity 177 Lu-DOTA-PSMA-617 and MCA 5–10 microns, 188 Re, from blood urine patients undergoing systemic local radiotherapy clinical trials. Materials methods: involved radiometry samples 12 m...

BACKGROUND In this paper, we evaluate the therapeutic and adverse effects of the application of 166-holmium-boro-macroaggregates (HMBA) in radiosynovectomy (RSO) of the knees. We assessed the efficacy and safety of (166)Ho-HBMA in a prospective clinical trial in patients suffering from chronic synovitis. MATERIAL AND METHODS An effective component of radiopharmaceutical (166)Ho-boro-macroaggr...

UNLABELLED Recently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst2-ANT was determined to have a high affinity for SSTR2. Additionally, 111In-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-sst2-ANT showed high uptake in an SSTR2-transfected, tumor-bearing mouse model and suggested that radiolabeled SSTR2 antagonists may be superior to agonists for imaging SSTR2-...

BACKGROUND: Radiosynovectomy is a therapy used to relieve pain and inflammation from rheumatoid arthritis and related diseases. In this study three 188Re particulate compounds were characterized according to their physico-chemical properties and their biological behavior in rabbits. The results were compared in order to establish which was the radiopharmaceutical that better fits the requiremen...

Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains radiation by specifically delivering tumors that can be well assessed terms of dosimetry and imaging. Dosimetry external beam is standard practice. This not case, however, RPT. NRG (acronym formed from first letter 3 original groups: National Surgical Adjuvant Breast Bowel Project,...

introduction:targeted radionuclide therapy (trt) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. trt is generally performed with a single radionuclide. in this study we investigated the feasibility of combined trt with a high-energy beta emitter (153sm) and a low energy beta emitter (177lu) in wistar rats. methods: the cocktail complex of...

introduction bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. nuclear medicine has an important role in helping the diagnosis of deep-seated infections by developing more specific radiopharmaceuticals. the aim of this study was to evaluate 99mtc-labeling ceftriaxone as a new radiopharmaceutical for staphylococcus aureus infection imag...

To provide an objective rapid means of excluding extrahepatic biliary atresia (atresia), a hepatic index was devised from the ratio of the net hepatic to cardiac distribution of 99mTc diisopropyl iminodiacetic acid or methylbrom iminodiacetic acid between 2.5 and 10 minutes after injection. The hepatic index was compared with subjective assessment of abdominal scintigraphy performed repeatedly ...