protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. chemicals capable of scavenging free radicals, relieving oxidative stress, promoting anti...

Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances reducing both acute and late radiation effects on healthy tissues are being developed. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it has...

*Corresponding author: Pِrof. Hossein Mozdarani, Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Fax: +98 21 88006544 E-mail: [email protected] Background: Radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells; how...

Radiation is an important source of free radicals in living systems. Ionizing radiations such as γ-rays exert their biological effects through generation of reactive oxygen species and the resultant damage to DNA and cellular membranes. Several natural compounds, especially with antioxidant abilities are known to be radioprotective. Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one), a...

Exposure to radiation can damage endothelial cells in the irradiated area via the production of reactive oxygen species. We synthesized phosphine-borane complexes that reduce disulfide bonds and had previously been shown to interfere with redox-mediated signaling of cell death. We hypothesized that this class of drugs could interfere with the downstream effects of oxidative stress after irradia...