PURPOSE To introduce the concept of dose-mass-based inverse optimization for radiotherapy applications. MATERIALS AND METHODS Mathematical derivation of the dose-mass-based formalism is presented. This mathematical representation is compared to the most commonly used dose-volume-based formulation used in inverse optimization. A simple example on digitally created phantom is presented. The pha...

The aim of this work is to develop and investigate an inverse treatment planning process (TPP) for mixed beam radiotherapy (MBRT) capable of performing simultaneous optimization of photon and electron apertures. A simulated annealing based direct aperture optimization (DAO) is implemented to perform simultaneous optimization of photon and electron apertures, both shaped with the photon multilea...

BED model (Biological Effective Dose) for Head and Neck tumors Hyperfractionation TPO was optimizedwith Pareto-Multiobjective (PMO) Genetic Algorithms (GA) software. Artificial Intelligence (AI) with GA is applied on Radiotherapy Treatment Planning Optimization (TPO). Secondly, the review of NEffective (Effective Tumor Population Clonogens Number) optimization breast cancer clonogens parameters...

radiotherapy is one of the most common treatments of cancer that are used alone or with the combination of other treatments. radiotherapy are used before surgery for tumor shrinking, pain relief, wound healing or prevention of continues bleedings. in this paper, types of radiotherapy and safety principles for nurses are considered. there are three basic methods for radiotherapy: teletherapy, br...

PURPOSE To introduce the concept of energy minimization-based inverse optimization for external beam radiotherapy. MATERIALS AND METHODS Mathematical formulation of energy minimization-based inverse optimization is presented. This mathematical representation is compared to the most commonly used dose-volume based formulation used in inverse optimization. A simple example on digitally created ...

A methodology for the concurrent optimization of beam orientations and beam weights in conformal radiotherapy treatment planning has been developed and tested on a cohort of five patients. The algorithm is based on a beam-weight optimization scheme with a downhill simplex optimization engine. The use of random voxels in the dose calculation provides much of the required speed up in the optimiza...

Cancer is a highly lethal disease that mainly treated by image-guided radiotherapy. Because the low dose of cone beam CT less harmful to patients, images are often used for target delineation in radiotherapy various cancers, especially breast and lung cancer. However, breathing heartbeat can cause position errors taken during different periods, also results insufficient imaging clarity, renderi...