نتایج جستجو برای: ras oncogene
تعداد نتایج: 70453 فیلتر نتایج به سال:
The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thus may serve as a potential diagnostic marker for cancer cells in circulation. Thi...
Activated i-lla-ras DNA sequences were introduced by transfection into a low passage simian virus 40 (SV40)-immortalized rat hepatocyte cell line, CYVSV1,and stable ras transfectant cell lines were established to determine the effect of the addition of the activated r-11a-ras oncogene on growth properties and differentiation. Control transfectant cell lines were generated by transfection with n...
RAS mutations are one of the most frequent molecular abnormalities associated with myeloid leukemia and preleukemia, yet there is a poor understanding of how they contribute to the pathogenesis of these conditions. Here, we describe the consequences of ectopic mutant N-Ras (N-Ras*) expression on normal human erythropoiesis. We show that during early (erythropoietin [EPO]-independent) erythropoi...
RAS mutations are one of the most frequent molecular abnormalities associated with myeloid leukaemia and preleukaemia, yet there is a poor understanding of how they contribute to the pathogenesis of these conditions. Here, we describe the consequences of ectopic mutant N-Ras (N-Ras*) expression on normal human erythropoiesis. We show that during early (EPO-independent) erythropoiesis, N-Ras* pr...
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