Results: TT treatment of diabetic rats reduced pain score only in chronic phase of the formalin test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05). Although TT treatment of diabetic rats i...

Evidence is presented that a polygalacturonic acid derivative (Stypturon) when administered intravenously to rats in nn optimal dosage results in concomitant diminution of blood loss from experimental injury to the tail. Mortality rate associated with hemorrhagic shock was significantly reduced. Blood coagulation was inhibited at the site of injury by immersion of the traumatized tail in an ant...

Transcutaneous electrical nerve stimulation (TENS) is an analgesia inducing method with increasing applications in clinical procedures. In this study we tried to evaluate the role of the adrenergic system and its different adrenoceptor subtypes in TENS-induced analgesia. Two types of low and high frequency electrical stimuli were used in rats through needle electrodes, inserted at the base ...

Isolated segments of the perfused rat tail artery display a high basal tone when compared to other isolated arteries such as the mesenteric and are suitable for the assay of vasopressor agents. However, the perfusion of this artery in the entire tail has not yet been used for functional studies. The main purpose of the present study was to identify some aspects of the vascular reactivity of the...

Previous research has demonstrated a link between rotational behavior and striatal dopamine asymmetry in the rat (rats rotate contralateral to the side of higher striatal dopamine concentration) and that the direction of a rat pup's tail posture will predict rotational bias. The present study hypothesized that neonatal tail posture would also predict adult striatal dopamine asymmetry. This hypo...

A series of thiazolidin-4-one (2a–h; 3a–h), azetidin-2-one (4a–h) and 1,3,4-oxadiazole (5a–h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. The structures of the new compounds were supported by their IR, 1H-NMR and mass spectral data. All compounds w...

Previous phytochemical analysis of methanolic extract of Corallocarpus epigaeus tuber (MCET) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Corallocarpus epigaeus tubers for possible analgesic anti-inflammatory ...