The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3- to 8-fold greater relative biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. As alpha particles typically cause DNA double-strand breaks (DSB), tar...

Our cell survival data showed the obvious dependence of RBE on photon energy: The RBE value for 200 kV X-rays was approximately 10% greater than those for mega-voltage photon beams. In radiation therapy using mega-voltage photon beams, the photon energy distribution outside the field is different with that in the radiation field because of a large number of low energy scattering photons. Hence,...

Ionizing radiation-induced foci (IRIF) of DNA repair-related proteins accumulated at DNA double-strand break (DSB) sites have been suggested to be a powerful biodosimetric tool. However, the relationship between IRIF induction and biologically relevant endpoints, such as cell death and formation of chromosome rearrangements is less clear, especial...

INTRODUCTION The purpose of this study was to evaluate the dosimetric and radiobiological impact of intensity modulated proton therapy (IMPT) and RapidArc planning for high-risk prostate cancer with seminal vesicles. METHODS Ten high-risk prostate cancer cases were included in this retrospective study. For each case, IMPT plans were generated using multiple field optimisation (MFO) technique ...

Introduction Currently, therapies using multipotent mescenchymal stem cells (MSCs) are tested clinically for various disorders, including cardiac disease [1]. However, conventional culture media contain fetal bovine serum (FBS) and so the concern about amphixenosis remains. Therefore, developing animal derived factor-free media are desired [2]. We previously reported that rice bran extract (RBE...

Linear Energy Transfer (LET) is widely used to express the radiation quality of ion beams, when characterizing biological effectiveness. However, averaged LET may be defined in multiple ways, and chosen definition impact resulting reported value. We review definitions found literature, quantify which using these various have for different reference setups. recorded 354 publications quantifying ...

Introduction In mammalian cell culture, fetal bovine serum (FBS) or proteins obtained from mammals are usually supplemented to culture media. Since the use of animal-derived components may cause an infection of virus and other pathogens, alternative supplement derived from nonmammals is eagerly required in cell culture for producing biotherapeutics and for cell therapy [1]. As an alternative su...