The first exclusive regioselective fragmentation of primary ozonides controlled by remote carbonyl groups on ozonolysis of norbornene derivatives and reaction of final ozonides with triethylamine as a new probe for determining the regiochemistry of carbonyl oxide formation from primary ozonide fragmentation are reported. Ozonolysis of the endo adducts 3a-d and the deuterated compounds 8a and 8b...

The title compound, C(12)H(15)NO, a degradation product of molindone hydro-chloride, was prepared by the reaction of molindone with methyl iodide and subsequent reaction of the resulting quaternary ammonium salt with 2N aqueous sodium hydroxide. The newly formed double bond is exocyclic in nature and the carbonyl group is conjugated with the π-electrons of the pyrrole ring. The six-membered rin...

Catalytic and photocatalytic reactions of (2-chloroethyl) phenyl sulfide (2-CEPS), a mimic of bis (2-chloroethyl)  sulfide (i.e. Sulfur mustard) were studied on the surfaces of titanium oxide. TiO2 nanoparticles (anatase, rutile and mixture of 80% anatase/20% rutile) along with bulk TiO2 were tested as reactive sorbents for reaction of 2-CEPS at room temperature (25±0.5°C). Reactions were monit...

A solvent-free approach for the post-synthetic functionalisation of polyethylene with carbonyl groups exclusively is described using oxygen as oxidant, industrially-relevant benzoic acid being sole organic side product reaction.

The carbonyl oxygen atom of the amide functional group is universally believed to be the thermodynamically preferred site of protonation in amides;[1] however, N protonation has been proposed to play a key role in biologically important reactions of peptides and proteins such as acid-catalyzed peptide hydrolysis[2] and cis ± trans isomerization about the CÿN bond.[3] Extensive research into the...

The reaction of copper(II) chloride and zinc(II) chloride with N-(2-methylphenyl)-3-(1'-salicylaldehydene-2'-imine-ethane)-butanamide(H2L2a) or (MPSB), N-(2-methylphenyl)-3-(1'-(3'-methoxysalicylaldehydene-2'-imine-ethane)-butanamide (H2L2b) or (MPMSB) and N-(2-methylphenyl)-3-(1'-(2'-hydroxyacetylene-2'-imine-ethane)-butanamide (H2L2c) (MPHB) leads to the formation of a series of new complexes...

Hydrogen sulfide (H2S) is an important biological signaling molecule, and chemical tools for H2S delivery and detection have emerged as important investigative methods. Key challenges in these fields include developing donors that are triggered to release H2S in response to stimuli and developing probes that do not irreversibly consume H2S. Here we report a new strategy for H2S donation based o...

Carbonyl sulfide (OCS) was photolyzed with linearly polarized 223 nm light and the sulfur-atom photofragment S(D2) was probed by (2 + 1) resonance enhanced multiphoton ionization (REMPI) using alternatively left and right circularly polarized light. The measured orientation of the angular momentum was found to depend strongly on the speed of the sulfur atom photofragment: fast S atoms show a la...

Reaction monitoring by electrospray ionization mass spectrometry (ESI-MS) is a popular method for investigation of reaction mechanisms. Here, we present new approach based on coupling between modular capillary flow reactor and ESI-MS. The allows sequential adding the reactants. We demonstrate oxidation Ph2S ArIO catalyzed [(TPA)Fe(TfO)2] (ArIO=2-(tBuSO2)C6H4IO, TPA=tris(2-pyridylmethyl)amine, T...

A theoretical study of the association phenyl and ortho-substituted aryl derivatives lactic acid was carried out. Two variants hydrogen-bonded associates in gas phase were calculated: non-classical, actually found crystals, simulated classical dimers. The energy advantage dimers non-equivalence diastereotopic electron lone pairs at carbonyl oxygen atom shown.