Bone metastases (BM) represent the most frequent indication for palliative radiotherapy in patients with breast cancer. BM increase the risk of skeletal-related events defined as pathological fractures, spinal cord compression, and, most frequently, bone pain. The therapeutic goals of palliative radiotherapy for BM are pain relief, recalcification, and stabilization, reducing spinal cord compre...

B LOOD PLATELETS observed in vivo normally circulate in the form of flat discs. Vascular injury results in the loss of platelet disc shape and adherence of the cells to damaged tissue.4’5 In vitro, sequential morphologic alterations follow the addition of calcium, adenosine diphosphate (ADP) and other aggregating agents to citrated platelet-rich plasma ( PRP) #{149}69The discoid form is lost, p...

Objective: This in vitro study examined the ability of Forté, based upon co-catalyzed calcium peroxide and carbamide peroxide (CaCP), to remineralize and recalcify pre-existing incipient lesions in tooth enamel, renewing the teeth while they are being whitened. • Methodology: Artificial lesions to 70-100 micrometers depth were created, simulating in vivo conditions. Calcium concentrations were ...

Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device...

Many studies have tried to look for the application of chitosan in tissue engineering since its structure is similar to glycoaminoglycans, the main components of the extracellular matrix. Previous studies had indicated that the incorporation of sulfonic or phosphonic functionalities would be beneficial to the growth of certain cells. However, no study has explored the effect of incorporation o...

The alveolar compartment in acute lung injury contains high levels of tissue factor (TF) procoagulant activity favoring fibrin deposition. We previously reported that the alveolar epithelium can release TF procoagulant activity in response to a proinflammatory stimulus. To test the hypothesis that the alveolar epithelium further modulates intra-alveolar fibrin deposition through secretion of an...

C1q receptors (C1qR) have been identified on a variety of somatic and cultured cells including peripheral blood platelets. Since platelets are likely to encounter both circulating C1q multimers and C1q associated with the extracellular matrix after complement activation by the classical pathway, the present study was designed to assess the effect of fluid phase and immobilized C1q on platelet f...

A thromboplastic factor has been demonstrated in human red cells by Shinowara (1951), Ottaviani, Dettori, and Manai (1954), Quick, Georgatsos, and Hussey (1954), Leupold (1955), Bounameaux (1957a), and Georgatsos, Hussey, and Quick (1955), and named the "erythrocyte clotting factor" (E.C.F.). Its activity is similar though not identical with that of platelet factor 3. Thromboplastic activity is...

Four patients with congenital defiother family were found to have varyciency of fibrin-stabilizing factor (facing degrees of factor XIII deficiency. tor XIII) from two families have been The observations support the hypothedescribed. The mother and the sibs in sis of autosomal recessive inheritance one family and both parents in the of factor XIII deficiency. T HE EXISTENCE OF A BLOOD FACTOR th...