A shared genetic pre-disposition, chronic inflammation, and treatment with similar biologics between Rheumatoid arthritis (RA) and Crohn's disease (CD) have intrigued us to investigate whether the two disorders share trigger association or possible causation. We hypothesized earlier that Single Nucleotide Polymorphisms (SNPs) in the negative regulators Protein Tyrosine Phosphatase Non-receptor ...

Computer simulation has been used to identify peptides that mimic the natural target of SARS-CoV-2 coronavirus spike (S) protein, angiotensin converting enzyme type 2 (ACE2) cell receptor. Based on structure complex protein S receptor-binding domain (RBD) and ACE2, design chimeric molecules consisting two 22-23-mer linked each other by disulfide bonds was carried out. The molecule X1 a dimer, i...

Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

Esophageal squamous cell carcinoma (ESCC) is the most prevalent malignant gastrointestinal tumor. Ion channels contribute to tumor growth and progression through interactions with their neighboring molecules including lipids. The dysregulation of membrane ion lipid metabolism may epithelial–mesenchymal transition (EMT), leading metastatic progression. Herein, transcriptome profiles patients ESC...

Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, Expression Farnesoid X Receptor, Liver Receptor Sirtuin 1 Genes in the Type Diabetic Rats