Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG 6000 solid dispersions have been determined by the methods of differential scanning calorimetry (DSC), X-ray dif...

background: in order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (ntcp), we consider the fractional dependence of the ntcp on the wall thickness (tw) and rectal displacement (rm). materials and methods: the two-dimensional ntcp model (ntcp2d) was developed using radiotherapy plans of ten randomly selected patients with prostat...

BACKGROUND COX-2 inhibitors have an antitumor potential and have been verified by many researchers. Treatment of cancer cells with external stressors such as irradiation can stimulate the over-expression of COX-2 and possibly confer radiation resistance. In this study, we tested if topical diclofenac, which inhibits both COX-1 and COX-2, administration rendered prostate tumor cells sensitize to...

Diclofenac potassium is a widely used non-steroid anti-inflammatory drug which is absorbed more quickly than diclofenac sodium, Reported cases of rhabdomyolisis after only diclofenac are rare, we survey three cases in the literature. . We report a case of a 50 year-old man, chronic smoker and allergic to aspirin who developed a rhabdomyolysis associated with glossopharyngeal edema after oral ad...

Purpose This study was performed to evaluate topical 1% diclofenac/3% menthol gel in treating ankle sprain. Design In this randomized, double-blind, placebo-controlled trial, adolescents and adults with acute ankle sprain (N = 385) applied 4 g of gel containing 1% diclofenac/3% menthol (n = 117), 1% diclofenac (n = 112), 3% menthol (n = 77), or placebo (n = 75) four times daily. The primary out...

Diclofenac belongs to non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective COX inhibitors. The aim of this study was to examine the effect of diclofenac on endothelial cell proliferation under the influence of hypoxia or inflammatory conditions. Another goal was to check whether diclofenac modulates the secretion of angiogenic factors such as VEGF and bFGF in human microvascular end...

The transformed monocyte/macrophage cell line J774.2 undergoes apoptosis when treated for 48 h with competitive inhibitors of cyclooxygenase (COX) isoenzymes 1 and 2. Many of these nonsteroid antiinflammatory drugs (NSAIDs), but in particular diclofenac, induce during this time period a COX activity that coincides with a robust induction of COX-2 protein. Induction of this activity requires hig...

Background and study aims: Several meta-analyses and randomized control trials have demonstrated the efficacy of rectal nonsteroidal anti-inflammatory drugs for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Diclofenac or indomethacin was administered at a dose of 100 mg in those studies, which may be too high for Asian population. In addition, rectal ...

The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic absorption. Two groups of rats were used; the test rats received a suspension containing the two prodrugs, diclofenac-β-cyclodextrin and sulfasalazin...