background: recurrent pregnancy loss (rpl) is defined as two or more miscarriages before the 20 th week of gestation and its etiology is unknown in 50% of the cases. interleukin 6 is an immune mediator, plays a regulatory role in embryo implantation and placental development. objective: the purpose was to assess the association between il-6 -634c/g polymorphism and, susceptibility to idiopathic...

Pregnancy loss can be caused by several factors involved in human reproduction. Although up to 50% of cases remain unexplained, it has been postulated that the major cause of failed pregnancy is an error of embryo implantation. Transmembrane mucin-1 (MUC-1) is a glycoprotein expressed on the endometrial cell surface which acts as a barrier to implantation. The gene that codes for this molecule ...

Congenital anomalies of the Müllerian ducts especially uterine abnormalities can affect negatively the different stages of fertility interfering with sperm migration, embryo implantation, normal placentation, fetal growth and achievement of a successful pregnancy. They are present in 2-10% of all women, three times greater in patients with recurrent pregnancy loss and lead to infertility and ad...

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...