The prevalence of polycystic ovaries in the women who had had recurrent miscarriages was high (82%). Although the number of parous control women was small, their prevalence of polycystic ovaries (18%) was similar to that observed in a much larger population of normal women (22%).3 The normal serum luteinising hormone and urine pregnanediol-3a-glucuronide concentrations suggest that the endocrin...

Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM. The aim of the present study was to identify the distribution of chromosome abnormalities among Tunisian couples with RM referred to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia) du...

Annexin A5 is a placental anti-coagulant protein that contains four nucleotide substitutions (M2 haplotype) in its promoter. Studies have shown that this haplotype is a risk factor for recurrent miscarriage (RM). Our aim was to investigate the influence of the M2 haplotype in the gestational timing of miscarriages, assessing the paternal risk and investigate for relationships with known risk fa...

Recurrent miscarriages are characterized as three or more spontaneous abortions in a row before the 20th week. In majority of instances, genetic factors, immunological and endocrine infection, unknown causes most common first trimester abortion. Hormonal therapy, heparin injection, immunotherapy available treatments. this case study, patient had during trimester. Because all tests came out norm...

background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...

Women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) are at a high risk of recurrent spontaneous miscarriages and late pregnancy complications. The prevalence of obstetric complications in aPL positive women is about 15-20%. The APS is defined by the combination of a clinical venous or arterial thrombotic event or a pregnancy complication and the laboratory detection...

OBJECTIVE To determine the association between the presence of anticardiolipin antibody (ACA) and history of recurrent spontaneous miscarriage. Also, to evaluate the association between raised ACA and activated partial thromboplastin time (APTT). METHODS This is a case-control study which was carried out in Basrah Hospital for Maternity and Children, Basrah, Iraq during January to September 2...

Some cases of recurrent first trimester miscarriage have a thrombotic etiology. The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. In this case-control study, we included 137 women with two o...