Background: Persistent elevation of parathyroid hormone (PPTH) levels following curative parathyroidectomy is a dynamic & multifactorial process. This study was designed to the frequency persistent hyperparathyroidism in our patients and identify potential causal factors for PTH parathyroidectomy.
 Methodology: The included prospectively collected data on post-operative primary who und...

Osteitis Fibrosa Cystica (OFC) is defined as the classic skeletal manifestation of advanced primary hyperparathyroidism. With the increased detection by means of routine calcium screening, the clinical profile of primary hyperparathyroidism in Western countries has shifted from symptomatic disease to one with subtle or no specific symptoms ("asymptomatic" primary hyperparathyroidism). The autho...

HYPOTHESIS A decrease in the intraoperative parathyroid hormone (PTH) level predicts long-term operative success. DESIGN A case series of consecutive patients undergoing parathyroidectomy with intraoperative PTH measurement. SETTING A university hospital. PATIENTS AND INTERVENTION One hundred two patients with sporadic primary hyperparathyroidism underwent parathyroidectomy according to t...

OBJECTIVE Asymptomatic primary hyperparathyroidism (PHPT) is routinely encountered in clinical practices of endocrinology throughout the world. This report distills an update of current information about diagnostics, clinical features, and management of this disease into a set of revised guidelines. PARTICIPANTS Participants, representing an international constituency, with interest and exper...

An ectopically placed parathyroid adenoma in the anterior mediastinum is a rare cause of persistent or recurrent primary hyperparathyroidism (PHPT) and is recognized as an important cause of failed primary neck exploration. We encountered 3 such cases amongst 70 surgically treated patients with PHPT (4.3%) over a 20-year period. In 2 cases, the offending adenoma could be removed at first explor...

Asymptomatic primary hyperparathyroidism (PHPT), a condition defined as hyperparathyroidism that lacks specific symptoms or signs and with calcium levels of less than 1 mg/dL above the upper limit of normal, is a common clinical problem. Two previous conferences on the management of asymptomatic PHPT (a Consensus Development Conference and a National Institutes of Health workshop) indicated tha...

Brown tumors also called as osteoclastomas, are rare nonneoplastic lesions that arise in the setting of primary or secondary hyperparathyroidism. Parathyroid adenomas or hyperplasia constitute the major Brown tumor source in primary hyperparathyroidism while chronic renal failure is the leading cause in secondary hyperparathyroidism. Most of the patients with the diagnosis of primary hyperparat...

An ectopically placed parathyroid adenoma in the anterior mediastinum is a rare cause of persistent or recurrent primary hyperparathyroidism (PHPT) and is recognized as an important cause of failed primary neck exploration. We encountered 3 such cases amongst 70 surgically treated patients with PHPT (4.3%) over a 20-year period. In 2 cases, the offending adenoma could be removed at first explor...

OBJECTIVE To examine the association between calcium intake and risk of primary hyperparathyroidism in women. DESIGN Prospective cohort study. SETTING Nurses' Health Study I, which originally recruited participants from the 11 most populous states in the United States. PARTICIPANTS 58,354 female registered nurses enrolled in the Nurses' Health Study I aged 39-66 years in 1986 and with no ...