نتایج جستجو برای: regulatory signal

تعداد نتایج: 590081  

Journal: :Molecular bioSystems 2013
Javier Estrada Raúl Guantes

Regulatory networks are able to process complex signals and respond appropriately to the cellular context. Thus, an increasing effort by systems biology researchers is being focused on understanding which interactions are responsible for a given functional response. When translated into specific mathematical models, however, it has been repeatedly shown that this mapping between topology and fu...

Journal: :middle east journal of cancer 0
ahmad nasser student research committee, ilam university of medical sciences, ilam, iran. ara khosravi associate professor of immunology, immunology dept., faculty of medicine, ilam university of medical sciences, ilam, iran mohamad taha gomravi student research committee, ilam university of medical sciences, ilam, iran reza azizian student research committee, ilam university of medical sciences, ilam, iran

t regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. t regulatory cells are produced in the thymus as a functionally mature subpopulation of t cells. they can be induced from naive t cells in the periphery and express their marker as a forkhead/winged helix transcription factor called fo...

Journal: :Journal of immunology 2005
Timo K van den Berg Ellen M van Beek Hans-Jörg Bühring Marco Colonna Michinari Hamaguchi Chris J Howard Masato Kasuga Yuan Liu Takashi Matozaki Benjamin G Neel Charles A Parkos Shin-ichiro Sano Agnès Vignery Eric Vivier Mark Wright Rainer Zawatzky A Neil Barclay

Journal: :Systems biology 2006
S Achimescu O Lipan

The ability to build genetic circuits with a reproducible response to external stimuli depends on the experimental and theoretical methods used in the process. A theoretical formalism that describes the response of a nonlinear stochastic genetic network to the external stimuli (input signals), is proposed. Two applications are studied in detail: the design of a logic pulse and the interference ...

2015
Julian Alvarez-Zarate Hanke L. Matlung Takashi Matozaki Taco W. Kuijpers Isabelle Maridonneau-Parini Timo K. van den Berg David D. Roberts

Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα...

Journal: :Annual review of immunology 1998
J D Klemm S L Schreiber G R Crabtree

Dynamic protein-protein interactions are a key component of biological regulatory networks. Dimerization events--physical interactions between related proteins--represent an important subset of protein-protein interactions and are frequently employed in transducing signals from the cell surface to the nucleus. Importantly, dimerization between different members of a protein family can generate ...

2018
Lu Qi Yanqing Ding

There are many stages in the development and metastasis of colorectal cancer (CRC). In this study, we compared the differential expression genes in different stages of metastatic CRC. Then, we screened the continuously up-regulated genes and the continuously down-regulated genes that were associated with the development and metastasis of CRC. After analyzing the intersection of differential exp...

Journal: :CoRR 2006
Qing Zhao Brian M. Sadler

II Spectrum Opportunity Identification 5 II-A Spectrum Opportunity and Interference Constraint: Definitions and Implications . . . . . . . . . 5 II-A.1 Spectrum Opportunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 II-A.2 Interference Constraint . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 II-B Spectrum Opportunity Detection . . . . . . . . ....

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